Technology Process of 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-(2-methyl-2H-1,2,3-triazole-4-yl)-6-(4-cyanophenyl)
There total 7 articles about 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-(2-methyl-2H-1,2,3-triazole-4-yl)-6-(4-cyanophenyl) which
guide to synthetic route it.
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synthetic route:
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1407834-62-1
4H-[1,2,4]riazolo[4,3-a][1,5] benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(4-cyano-phenyl)
- Guidance literature:
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With
potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; water;
at 100 ℃;
for 0.5h;
under 12901.3 Torr;
Microwave irradiation;
- Guidance literature:
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Multi-step reaction with 7 steps
1: ammonium chloride; iron / ethanol; water / 2 h / 60 °C
2: sodium / methanol / 0 - 20 °C
3: Lawessons reagent / tetrahydrofuran / 12 h / 80 °C
4: butan-1-ol / 12 h / 130 °C
5: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 180 °C / 12901.3 Torr / Microwave irradiation
6: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 0.33 h / 110 °C / 12901.3 Torr / Microwave irradiation
7: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / water; tetrahydrofuran / 0.5 h / 100 °C / 12901.3 Torr / Microwave irradiation
With
Lawessons reagent; potassium acetate; sodium; iron; potassium carbonate; ammonium chloride;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; butan-1-ol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium / methanol / 0 - 20 °C
2: Lawessons reagent / tetrahydrofuran / 12 h / 80 °C
3: butan-1-ol / 12 h / 130 °C
4: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 180 °C / 12901.3 Torr / Microwave irradiation
5: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 0.33 h / 110 °C / 12901.3 Torr / Microwave irradiation
6: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / water; tetrahydrofuran / 0.5 h / 100 °C / 12901.3 Torr / Microwave irradiation
With
Lawessons reagent; potassium acetate; sodium; potassium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; butan-1-ol;