1-(4-Methylphenyl)-1,2,3,4-tetrahydro-3-carbomethoxy-β-carboline

Base Information

• Chemical Name: 1-(4-Methylphenyl)-1,2,3,4-tetrahydro-3-carbomethoxy-β-carboline
• CAS No.: 82789-32-0
• Molecular Formula: C₂₀H₂₀N₂O₂
• Molecular Weight: 320.391
• Mol file: 82789-32-0.mol

Synonyms:1-(4-Methylphenyl)-1,2,3,4-tetrahydro-3-carbomethoxy-β-carboline

Chemical Property of 1-(4-Methylphenyl)-1,2,3,4-tetrahydro-3-carbomethoxy-β-carboline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-Methylphenyl)-1,2,3,4-tetrahydro-3-carbomethoxy-β-carboline

There total 12 articles about 1-(4-Methylphenyl)-1,2,3,4-tetrahydro-3-carbomethoxy-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-benzaldehyde (104-87-0) + L-tryptophan methyl ester (4299-70-1) → 1-(4-Methylphenyl)-1,2,3,4-tetrahydro-3-carbomethoxy-β-carboline (82789-32-0)

Guidance literature:

With [bdmim][PF₆]; trifluoroacetic acid; In tetrahydrofuran; at 60 ℃; for 0.00694444h; microwave irradiation;

DOI:10.1016/j.tetlet.2004.09.056

Reference yield:

4-methyl-benzaldehyde (104-87-0) + (S)-tryptophan methyl ester hydrochloride (7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8) → 1-(4-Methylphenyl)-1,2,3,4-tetrahydro-3-carbomethoxy-β-carboline (82789-32-0)

Guidance literature:

With sodium carbonate; In methanol;

DOI:10.1021/jm9800705

Reference yield:

C19H18N2O2 (82789-23-9) → 1-(4-Methylphenyl)-1,2,3,4-tetrahydro-3-carbomethoxy-β-carboline (82789-32-0)

Guidance literature:

With thionyl chloride; In methanol; at 0 ℃; Reflux;

DOI:10.1111/cbdd.13752

upstream raw materials:

4-methyl-benzaldehyde

DL-tryptophan methyl ester

Trp

(S)-tryptophan methyl ester hydrochloride