(R)-3-[(2-phenethyl-oxiranecarbonyl)-amino]-benzoic acid tert-butyl ester

Base Information

Chemical Name:(R)-3-[(2-phenethyl-oxiranecarbonyl)-amino]-benzoic acid tert-butyl ester
CAS No.:1268152-09-5
Molecular Formula:C₂₂H₂₅NO₄
Molecular Weight:367.445
Hs Code.:

Synonyms:(R)-3-[(2-phenethyl-oxiranecarbonyl)-amino]-benzoic acid tert-butyl ester

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Chemical Property of (R)-3-[(2-phenethyl-oxiranecarbonyl)-amino]-benzoic acid tert-butyl ester

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Technology Process of (R)-3-[(2-phenethyl-oxiranecarbonyl)-amino]-benzoic acid tert-butyl ester

There total 3 articles about (R)-3-[(2-phenethyl-oxiranecarbonyl)-amino]-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268152-16-4
C₁₁H₁₂O₃

: 92146-82-2
tert-butyl 3-aminobenzoate

: 1268152-09-5
(R)-3-[(2-phenethyl-oxiranecarbonyl)-amino]-benzoic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; at 30 ℃; for 3h;
DOI:10.1016/j.bmc.2010.11.042

Reference yield:

: 2-phenethyloxirane-2-carboxylic acid ethyl ester

: 1268152-09-5
(R)-3-[(2-phenethyl-oxiranecarbonyl)-amino]-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Reprosil Chiral NR column / 2-Methylpentane; isopropyl alcohol / Resolution of racemate

2: ethanol; potassium hydroxide / 2 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / 3 h / 30 °C

With ethanol; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In 2-Methylpentane; isopropyl alcohol;
DOI:10.1016/j.bmc.2010.11.042

Reference yield:

: 1268152-06-2
C₁₃H₁₆O₃

: 1268152-09-5
(R)-3-[(2-phenethyl-oxiranecarbonyl)-amino]-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol; potassium hydroxide / 2 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / 3 h / 30 °C

With ethanol; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide;
DOI:10.1016/j.bmc.2010.11.042