N-Isopropyl-2-[3-(4-methoxy-phenyl)-6-oxo-5,6-dihydro-4H-pyridazin-1-yl]-acetamide

Base Information

Chemical Name:N-Isopropyl-2-[3-(4-methoxy-phenyl)-6-oxo-5,6-dihydro-4H-pyridazin-1-yl]-acetamide
CAS No.:142731-53-1
Molecular Formula:C₁₆H₂₁N₃O₃
Molecular Weight:303.361
Hs Code.:

Synonyms:N-Isopropyl-2-[3-(4-methoxy-phenyl)-6-oxo-5,6-dihydro-4H-pyridazin-1-yl]-acetamide

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Chemical Property of N-Isopropyl-2-[3-(4-methoxy-phenyl)-6-oxo-5,6-dihydro-4H-pyridazin-1-yl]-acetamide

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Technology Process of N-Isopropyl-2-[3-(4-methoxy-phenyl)-6-oxo-5,6-dihydro-4H-pyridazin-1-yl]-acetamide

There total 4 articles about N-Isopropyl-2-[3-(4-methoxy-phenyl)-6-oxo-5,6-dihydro-4H-pyridazin-1-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 127806-50-2
[3-(4-Methoxy-phenyl)-6-oxo-5,6-dihydro-4H-pyridazin-1-yl]-acetic acid

: 75-31-0
isopropylamine

: 142731-53-1
N-Isopropyl-2-[3-(4-methoxy-phenyl)-6-oxo-5,6-dihydro-4H-pyridazin-1-yl]-acetamide

Guidance literature:: With triethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 3h;

Reference yield:

: 1017-06-7
6-(4-Methoxyphenyl)-4,5-dihydro-2H-pyridazin-3-one

: 142731-53-1
N-Isopropyl-2-[3-(4-methoxy-phenyl)-6-oxo-5,6-dihydro-4H-pyridazin-1-yl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, room temperature, 30 min, 2.) room temperature

2: 80 percent / aqueous LiOH / methanol / Ambient temperature

3: 57 percent / N(C₂H₅)3, triethyl cyanophosphonate / dimethylformamide / 3 h / 0 °C

With lithium hydroxide; triethyl cyanophosphonate; sodium hydride; triethylamine; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 142731-44-0
[3-(4-Methoxy-phenyl)-6-oxo-5,6-dihydro-4H-pyridazin-1-yl]-acetic acid methyl ester

: 142731-53-1
N-Isopropyl-2-[3-(4-methoxy-phenyl)-6-oxo-5,6-dihydro-4H-pyridazin-1-yl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / aqueous LiOH / methanol / Ambient temperature

2: 57 percent / N(C₂H₅)3, triethyl cyanophosphonate / dimethylformamide / 3 h / 0 °C

With lithium hydroxide; triethyl cyanophosphonate; triethylamine; In methanol; N,N-dimethyl-formamide;