2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-4-((pyridin-4-yl)amino)pyrimidin-5-ol

Base Information

• Chemical Name: 2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-4-((pyridin-4-yl)amino)pyrimidin-5-ol
• CAS No.: 1445830-51-2
• Molecular Formula: C₂₅H₂₄F₂N₆O₂
• Molecular Weight: 478.501

Synonyms:2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-4-((pyridin-4-yl)amino)pyrimidin-5-ol

Chemical Property of 2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-4-((pyridin-4-yl)amino)pyrimidin-5-ol

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Technology Process of 2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-4-((pyridin-4-yl)amino)pyrimidin-5-ol

There total 4 articles about 2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-4-((pyridin-4-yl)amino)pyrimidin-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine (1445830-50-1) → 2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-4-((pyridin-4-yl)amino)pyrimidin-5-ol (1445830-51-2)

Guidance literature:

With potassium carbonate; thiophenol; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 2h; Molecular sieve;

Reference yield: 56.0%

2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine (1445830-50-1) + thiophenol (108-98-5) → 2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-4-((pyridin-4-yl)amino)pyrimidin-5-ol (1445830-51-2)

Guidance literature:

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 150 ℃;

Reference yield: 56.0%

2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine (1445830-50-1) + thiophenol (108-98-5) → 2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-4-((pyridin-4-yl)amino)pyrimidin-5-ol (1445830-51-2) + 2-{5-cyclopropyl-1-[4-ethoxy-2-fluoro-6-(phenylsulfanyl)benzyl]-4-methyl-1H-pyrazol-3-yl}-4-((pyridin-4-yl)amino)pyrimidin-5-ol (1445830-52-3)

Guidance literature:

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 2h; Molecular sieve;

upstream raw materials:

2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

thiophenol

2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxypyrimidin-4-amine

Downstream raw materials:

2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-5-[2-(dimethylamino)ethoxy]-N-(pyridin-4-yl)pyrimidin-4-amine

2-[5-cyclopropyl-1-(4-ethoxy-2,6-difiuorobenzyl)-4-methyl-1H-pyrazol-3-yl]-5-[3-(methylsulfinyl)propoxy]-N-(pyridin-4-yl)pyrimidin-4-amine

2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-5-[3-(methylsulfanyl)propoxy]-N-(pyridin-4-yl)-pyrimidin-4-amine

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