tert-butyl (S)-((S)-1-cyano-2-oxocyclopentyl)(phenyl)methylcarbamate

Base Information

• Chemical Name: tert-butyl (S)-((S)-1-cyano-2-oxocyclopentyl)(phenyl)methylcarbamate
• CAS No.: 1123681-60-6
• Molecular Formula: C₁₈H₂₂N₂O₃
• Molecular Weight: 314.384
• Mol file: 1123681-60-6.mol

Synonyms:tert-butyl (S)-((S)-1-cyano-2-oxocyclopentyl)(phenyl)methylcarbamate

Chemical Property of tert-butyl (S)-((S)-1-cyano-2-oxocyclopentyl)(phenyl)methylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of tert-butyl (S)-((S)-1-cyano-2-oxocyclopentyl)(phenyl)methylcarbamate

There total 7 articles about tert-butyl (S)-((S)-1-cyano-2-oxocyclopentyl)(phenyl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

benzaldehyde N-boc imine (150884-50-7) + 2-oxocyclopentanecarbonitrile (2941-29-9,138260-51-2) → tert-butyl (S)-((S)-1-cyano-2-oxocyclopentyl)(phenyl)methylcarbamate (1123681-60-6)

Guidance literature:

With C₃₇H₃₁F₆N₃O; In toluene; at -78 ℃; for 1.16667h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/adsc.200900268

Reference yield:

benzaldehyde N-boc imine (150884-50-7) + 2-oxocyclopentanecarbonitrile (2941-29-9,138260-51-2) → tert-butyl (S)-((S)-1-cyano-2-oxocyclopentyl)(phenyl)methylcarbamate (1123681-60-6) + tert-butyl (R)-((R)-1-cyano-2-oxocyclopentyl)(phenyl)methylcarbamate

Guidance literature:

With C₃₇H₃₁F₆N₃O; In toluene; at -40 ℃; for 0.8h; enantioselective reaction;

DOI:10.1002/adsc.200900268

Reference yield:

benzaldehyde N-boc imine (150884-50-7) + 2-oxocyclopentanecarbonitrile (2941-29-9,138260-51-2) → tert-butyl (S)-((S)-1-cyano-2-oxocyclopentyl)(phenyl)methylcarbamate (1123681-60-6) + tert-butyl (R)-((R)-1-cyano-2-oxocyclopentyl)(phenyl)methylcarbamate + C18H22N2O3 (1219681-42-1)

Guidance literature:

With 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea; In toluene; at 20 ℃; for 0.3h; enantioselective reaction;

DOI:10.1002/adsc.200900268

upstream raw materials:

benzaldehyde N-boc imine

2-oxocyclopentanecarbonitrile