N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(2-thienyl)acetamide

Base Information

Chemical Name:N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(2-thienyl)acetamide
CAS No.:941318-38-3
Molecular Formula:C₂₃H₁₆ClN₅OS
Molecular Weight:445.932
Hs Code.:

Synonyms:N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(2-thienyl)acetamide

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Chemical Property of N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(2-thienyl)acetamide

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Technology Process of N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(2-thienyl)acetamide

There total 1 articles about N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(2-thienyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 39098-97-0
2-thienylacetic acid chloride

: 895635-70-8
{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}amine

: 941318-38-3
N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(2-thienyl)acetamide

Guidance literature:: 2-thienylacetic acid chloride; {3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}amine; With triethylamine; In tetrahydrofuran;

With PS-Trisamine; In tetrahydrofuran; for 16h;

Reference yield: 66.0%

: 895637-60-2
N-[(3-aminophenyl)methyl]-N-[2-(dimethylamino)ethyl]-2,2,2-trifluoroacetamide

: 941318-38-3
N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(2-thienyl)acetamide

: 941318-94-1
N-{3-[3-(2-{[3-({[2-(dimethylamino)ethyl]amino}methyl)phenyl]-amino}-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(2-thienyl)acetamide

Guidance literature:: hydrogenchloride; In isopropyl alcohol; at 180 ℃; for 0.416667h; Microwave irradiation;

Reference yield: 63.0%

: 895637-68-0
N-[(3-Aminophenyl)methyl]-2,2,2-trifluoro-N-[2-(methylsulfonyl)ethyl]-acetamide

: 941318-38-3
N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(2-thienyl)acetamide

: 941318-96-3
2,2,2-trifluoro-N-[2-(methylsulfonyl)ethyl]-N-[(3-{[4-(2-{3-[(2-thienylacetyl)amino]phenyl}pyrazolo[1,5-a]pyridin-3-yl)-2-pyrimidinyl]amino}phenyl)methyl]acetamide

Guidance literature:: N-[(3-Aminophenyl)methyl]-2,2,2-trifluoro-N-[2-(methylsulfonyl)ethyl]-acetamide; N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(2-thienyl)acetamide; hydrogenchloride; In water; isopropyl alcohol; at 180 ℃; for 0.25h; Microwave irradiation;

With water; sodium hydrogencarbonate; In ethyl acetate; isopropyl alcohol;