(S)-5-(acetoxymethyloxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2-(1H)-pyridone

Base Information

Chemical Name:(S)-5-(acetoxymethyloxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2-(1H)-pyridone
CAS No.:1614264-52-6
Molecular Formula:C₁₆H₁₆N₂O₇
Molecular Weight:348.312
Hs Code.:

Synonyms:(S)-5-(acetoxymethyloxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2-(1H)-pyridone

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Chemical Property of (S)-5-(acetoxymethyloxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2-(1H)-pyridone

Chemical Property:

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Technology Process of (S)-5-(acetoxymethyloxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2-(1H)-pyridone

There total 9 articles about (S)-5-(acetoxymethyloxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2-(1H)-pyridone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1614264-63-9
(±)-5-(acetoxymethyloxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2-(1H)-pyridone

: 1614264-52-6
(S)-5-(acetoxymethyloxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2-(1H)-pyridone

Guidance literature:: With Candida antarctica lipase B; water; In tert-butyl methyl ether; at 28 ℃; for 2h; Enzymatic reaction;
DOI:10.1016/j.tet.2014.05.012

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 1614264-52-6
(S)-5-(acetoxymethyloxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2-(1H)-pyridone

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; ammonium acetate / 9 h / 80 °C / Reflux

2.1: trifluoroacetic acid / dichloromethane / 0 °C

3.1: caesium carbonate / N,N-dimethyl-formamide

3.2: 20 °C

4.1: water; Candida antarctica lipase B / tert-butyl methyl ether / 2 h / 28 °C / Enzymatic reaction

With Candida antarctica lipase B; ammonium acetate; water; caesium carbonate; acetic acid; trifluoroacetic acid; In dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2014.05.012

Reference yield:

: 423120-04-1
2-methyl-4-(3-nitro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid

: 1614264-52-6
(S)-5-(acetoxymethyloxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2-(1H)-pyridone

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide

1.2: 20 °C

2.1: water; Candida antarctica lipase B / tert-butyl methyl ether / 2 h / 28 °C / Enzymatic reaction

With Candida antarctica lipase B; water; caesium carbonate; In tert-butyl methyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2014.05.012