(4R,8E)-2-amino-5,6,7,8-tetrahydro-6-methyl-4-(3-nitrophenyl)-8-(3-nitrophenylmethylene)-4H-pyrano[3,2-c]pyridine-3-carbonitrile

Base Information

• Chemical Name: (4R,8E)-2-amino-5,6,7,8-tetrahydro-6-methyl-4-(3-nitrophenyl)-8-(3-nitrophenylmethylene)-4H-pyrano[3,2-c]pyridine-3-carbonitrile
• CAS No.: 1289514-59-5
• Molecular Formula: C₂₃H₁₉N₅O₅
• Molecular Weight: 445.434
• Mol file: 1289514-59-5.mol

Synonyms:(4R,8E)-2-amino-5,6,7,8-tetrahydro-6-methyl-4-(3-nitrophenyl)-8-(3-nitrophenylmethylene)-4H-pyrano[3,2-c]pyridine-3-carbonitrile

Chemical Property of (4R,8E)-2-amino-5,6,7,8-tetrahydro-6-methyl-4-(3-nitrophenyl)-8-(3-nitrophenylmethylene)-4H-pyrano[3,2-c]pyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,8E)-2-amino-5,6,7,8-tetrahydro-6-methyl-4-(3-nitrophenyl)-8-(3-nitrophenylmethylene)-4H-pyrano[3,2-c]pyridine-3-carbonitrile

There total 2 articles about (4R,8E)-2-amino-5,6,7,8-tetrahydro-6-methyl-4-(3-nitrophenyl)-8-(3-nitrophenylmethylene)-4H-pyrano[3,2-c]pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(3E,5E)-1-methyl-3,5-bis(3-nitrobenzylidene)piperidin-4-one (920030-44-0) + malononitrile (109-77-3) → (4R,8E)-2-amino-5,6,7,8-tetrahydro-6-methyl-4-(3-nitrophenyl)-8-(3-nitrophenylmethylene)-4H-pyrano[3,2-c]pyridine-3-carbonitrile (1289514-59-5)

Guidance literature:

With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(piperidin-1-yl)cyclohexyl)thiourea; In toluene; at 20 ℃; for 40h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/jo200112r

Reference yield:

N-methyl-3,5-bis(3-nitrophenylmethylene)-4-piperidone (303789-15-3) + malononitrile (109-77-3) → (4R,8E)-2-amino-5,6,7,8-tetrahydro-6-methyl-4-(3-nitrophenyl)-8-(3-nitrophenylmethylene)-4H-pyrano[3,2-c]pyridine-3-carbonitrile (1289514-59-5) + (4S,8E)-2-amino-5,6,7,8-tetrahydro-6-methyl-4-(3-nitrophenyl)-8-(3-nitrophenylmethylene)-4H-pyrano[3,2-c]pyridine-3-carbonitrile (1446347-78-9)

Guidance literature:

With quinine; In toluene; at 20 ℃; for 72h; Overall yield = 99 %; enantioselective reaction;

DOI:10.3998/ark.5550190.0014.301

upstream raw materials:

(3E,5E)-1-methyl-3,5-bis(3-nitrobenzylidene)piperidin-4-one

malononitrile

N-methyl-3,5-bis(3-nitrophenylmethylene)-4-piperidone