(1R,3R,4S)-3-Menthyl-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinoline carboxylate)

Base Information

• Chemical Name: (1R,3R,4S)-3-Menthyl-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinoline carboxylate)
• CAS No.: 129958-91-4
• Molecular Formula: C₂₂H₃₃NO₄
• Molecular Weight: 375.508
• Mol file: 129958-91-4.mol

Synonyms:(1R,3R,4S)-3-Menthyl-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinoline carboxylate)

Chemical Property of (1R,3R,4S)-3-Menthyl-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinoline carboxylate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3R,4S)-3-Menthyl-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinoline carboxylate)

There total 1 articles about (1R,3R,4S)-3-Menthyl-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinoline carboxylate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(1R,2S,5R)-menthyl chloroformate (14602-86-9,7635-53-2) → (1R,3R,4S)-3-Menthyl-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinoline carboxylate) (129958-91-4)

Guidance literature:

With triethylamine; In dichloromethane; 1) 0 deg C, 15 min, 2) RT, 3.5 h;

DOI:10.1002/ardp.19903230605

Reference yield:

(1R,3R,4S)-3-Menthyl-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinoline carboxylate) (129958-91-4) → C22H32NO4(1+)*BF4(1-)

Guidance literature:

With trityl tetrafluoroborate; In dichloromethane; for 16h; Ambient temperature;

DOI:10.1002/ardp.19903230605

Reference yield:

(1R,3R,4S)-3-Menthyl-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinoline carboxylate) (129958-91-4) → (1R,3R,4S)-3-Menthyl-<1,2,3,4-tetrahydro-6,7-dimethoxy-1-(2-oxo-2-phenyl-1-ethyl)-2-isoquinoline carboxylate> (129958-92-5,129958-93-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Ph₃C(+)*BF₄(-) / CH₂Cl₂ / 16 h / Ambient temperature

2: 3 h / -78 °C

With trityl tetrafluoroborate; In dichloromethane;

DOI:10.1002/ardp.19903230605

upstream raw materials:

(1R,2S,5R)-menthyl chloroformate

Downstream raw materials:

(1R,3R,4S)-3-Menthyl-<1,2,3,4-tetrahydro-6,7-dimethoxy-1-(2-oxo-2-phenyl-1-ethyl)-2-isoquinoline carboxylate>