tert-butyl ((2R,3R)-4-hydroxy-2,3-dimethylbutyl)(4-methoxybenzyl)carbamate

Base Information

Chemical Name:tert-butyl ((2R,3R)-4-hydroxy-2,3-dimethylbutyl)(4-methoxybenzyl)carbamate
CAS No.:1312473-02-1
Molecular Formula:C₁₉H₃₁NO₄
Molecular Weight:337.459
Hs Code.:

Synonyms:tert-butyl ((2R,3R)-4-hydroxy-2,3-dimethylbutyl)(4-methoxybenzyl)carbamate

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Chemical Property of tert-butyl ((2R,3R)-4-hydroxy-2,3-dimethylbutyl)(4-methoxybenzyl)carbamate

Chemical Property:

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Technology Process of tert-butyl ((2R,3R)-4-hydroxy-2,3-dimethylbutyl)(4-methoxybenzyl)carbamate

There total 4 articles about tert-butyl ((2R,3R)-4-hydroxy-2,3-dimethylbutyl)(4-methoxybenzyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1312473-01-0
(2R,3R)-4-((4-methoxybenzyl)amino)-2,3-dimethylbutan-1-ol

: 1312473-02-1
tert-butyl ((2R,3R)-4-hydroxy-2,3-dimethylbutyl)(4-methoxybenzyl)carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol201448h

Reference yield:

: 1312473-00-9
(2R,3R)-4-((4-methoxybenzyl)amino)-2,3-dimethyl-4-oxobutanoic acid

: 1312473-02-1
tert-butyl ((2R,3R)-4-hydroxy-2,3-dimethylbutyl)(4-methoxybenzyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 15 h / 0 °C / Inert atmosphere; Reflux

2: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With dimethylsulfide borane complex; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol201448h

Reference yield:

: 5866-39-7
L(+)-tartaric acid

: 1312473-02-1
tert-butyl ((2R,3R)-4-hydroxy-2,3-dimethylbutyl)(4-methoxybenzyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic anhydride / dichloromethane / 1 h / 0 °C / Inert atmosphere

2: dmap; triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

3: dimethylsulfide borane complex / tetrahydrofuran / 15 h / 0 °C / Inert atmosphere; Reflux

4: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With dmap; dimethylsulfide borane complex; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol201448h