2,5-difluoro-4-(3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)benzenamine

Base Information

Chemical Name:2,5-difluoro-4-(3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)benzenamine
CAS No.:1225283-32-8
Molecular Formula:C₁₅H₁₂F₂N₄O
Molecular Weight:302.283
Hs Code.:

Synonyms:2,5-difluoro-4-(3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)benzenamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,5-difluoro-4-(3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)benzenamine

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Technology Process of 2,5-difluoro-4-(3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)benzenamine

There total 4 articles about 2,5-difluoro-4-(3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1225278-74-9
4-(3-bromopyridin-4-yloxy)-2,5-difluorobenzenamine

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1225283-32-8
2,5-difluoro-4-(3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)benzenamine

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; Inert atmosphere;

Reference yield:

: 36953-42-1
3-bromo-4-chloropyridine

: 1225283-32-8
2,5-difluoro-4-(3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)benzenamine

Guidance literature:: Multi-step reaction with 3 steps

1: chlorobenzene / 145 °C

2: tin(II) chloride dihdyrate / ethanol / 4 h / 80 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 90 °C / Inert atmosphere

With tin(II) chloride dihdyrate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; chlorobenzene;

Reference yield:

: 120103-18-6
2.5-difluoro-4-nitrophenol

: 1225283-32-8
2,5-difluoro-4-(3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)benzenamine

Guidance literature:: Multi-step reaction with 3 steps

1: chlorobenzene / 145 °C

2: tin(II) chloride dihdyrate / ethanol / 4 h / 80 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 90 °C / Inert atmosphere

With tin(II) chloride dihdyrate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; chlorobenzene;