1,2-Distearoyl-3-{(S)-N-tert-butoxycarbonyl-4-[bis(2-chloroethyl)amino]phenylalanyl}glycerol

Base Information

• Chemical Name: 1,2-Distearoyl-3-{(S)-N-tert-butoxycarbonyl-4-[bis(2-chloroethyl)amino]phenylalanyl}glycerol
• CAS No.: 163333-46-8
• Molecular Formula: C₅₇H₁₀₀Cl₂N₂O₈
• Molecular Weight: 1012.34

Synonyms:1,2-Distearoyl-3-{(S)-N-tert-butoxycarbonyl-4-[bis(2-chloroethyl)amino]phenylalanyl}glycerol

Chemical Property of 1,2-Distearoyl-3-{(S)-N-tert-butoxycarbonyl-4-[bis(2-chloroethyl)amino]phenylalanyl}glycerol

Chemical Property:

Purity/Quality:

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Technology Process of 1,2-Distearoyl-3-{(S)-N-tert-butoxycarbonyl-4-[bis(2-chloroethyl)amino]phenylalanyl}glycerol

There total 2 articles about 1,2-Distearoyl-3-{(S)-N-tert-butoxycarbonyl-4-[bis(2-chloroethyl)amino]phenylalanyl}glycerol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 1,2-Distearoyl-3-{(S)-N-tert-butoxycarbonyl-4-[bis(2-chloroethyl)amino]phenylalanyl}glycerol (163333-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / NaOH / H₂O; dioxane / 16 h / Ambient temperature

2: 18 percent / BOP, HOBt, DIPEA / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water;

DOI:10.1016/S0223-5234(97)89087-3

Reference yield:

L-PAM (148-82-3,8057-25-8) → 1,2-Distearoyl-3-{(S)-N-tert-butoxycarbonyl-4-[bis(2-chloroethyl)amino]phenylalanyl}glycerol (163333-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / NaOH / H₂O; dioxane / 16 h / Ambient temperature

2: 18 percent / BOP, HOBt, DIPEA / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water;

DOI:10.1016/S0223-5234(97)89087-3

Reference yield: 69.0%

1,2-Distearoyl-3-{(S)-N-tert-butoxycarbonyl-4-[bis(2-chloroethyl)amino]phenylalanyl}glycerol (163333-46-8) → Octadecanoic acid 2-((S)-2-amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionyloxy)-1-octadecanoyloxymethyl-ethyl ester; hydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 0.166667h; Ambient temperature;

DOI:10.1016/S0223-5234(97)89087-3

upstream raw materials:

di-tert-butyl dicarbonate

L-PAM

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