(1S,2S)-2-[2-Fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-4-methylene-cyclopentanecarboxylic acid ethyl ester

Base Information

Chemical Name:(1S,2S)-2-[2-Fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-4-methylene-cyclopentanecarboxylic acid ethyl ester
CAS No.:886839-77-6
Molecular Formula:C₂₁H₂₁FN₂O₄
Molecular Weight:384.407
Hs Code.:

Synonyms:(1S,2S)-2-[2-Fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-4-methylene-cyclopentanecarboxylic acid ethyl ester

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Chemical Property of (1S,2S)-2-[2-Fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-4-methylene-cyclopentanecarboxylic acid ethyl ester

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Technology Process of (1S,2S)-2-[2-Fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-4-methylene-cyclopentanecarboxylic acid ethyl ester

There total 1 articles about (1S,2S)-2-[2-Fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-4-methylene-cyclopentanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 536747-52-1
1-(4-amino-3-fluoro-phenyl)-pyridin-2-one

: 886839-77-6
(1S,2S)-2-[2-Fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-4-methylene-cyclopentanecarboxylic acid ethyl ester

Guidance literature:: trans-(1SR,2SR)-4-methylene-cyclopentane-1,2-dicarboxylic acid ethyl ester; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -15 - 20 ℃; for 1.5h;

1-(4-amino-3-fluoro-phenyl)-pyridin-2-one; In tetrahydrofuran; N,N-dimethyl-formamide; at 60 ℃; for 1h;

Reference yield: 79.0%

: 886839-77-6
(1S,2S)-2-[2-Fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-4-methylene-cyclopentanecarboxylic acid ethyl ester

: (1S,2S)-4-methylene-cyclopentane-1,2-dicarboxylic acid 1-[(5-chloro-pyridin-2-yl)-amide] 2-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide}

Guidance literature:: 5-chloro-2-pyridylamine; With trimethylaluminum; In toluene; at 20 ℃; for 1h;

(1S,2S)-2-[2-Fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-4-methylene-cyclopentanecarboxylic acid ethyl ester; In toluene; for 2h; Heating / reflux;