1-fluoro-2-propylbenzene

Base Information

• Chemical Name: 1-fluoro-2-propylbenzene
• CAS No.: 912551-99-6
• Molecular Formula: C₉H₁₁F
• Molecular Weight: 138.185
• Mol file: 912551-99-6.mol

Synonyms:1-fluoro-2-propylbenzene

Chemical Property of 1-fluoro-2-propylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-fluoro-2-propylbenzene

There total 8 articles about 1-fluoro-2-propylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-fluoro-1-(3-iodopropyl)benzene (201486-97-7) → 1-fluoro-2-propylbenzene (912551-99-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 24h;

DOI:10.1002/ejoc.201901135

Reference yield:

1-chloro-2-fluorobenzene (348-51-6) → 1-fluoro-2-iso-propylbenzene (2022-67-5) + 1-fluoro-2-propylbenzene (912551-99-6)

Guidance literature:

1-chloro-2-fluorobenzene; With C₃₇H₆₀P₂*C₁₃H₁₅^(1-)*Cl^(1-)*Pd⁽²⁺⁾; In diethyl ether; Schlenk technique; Inert atmosphere;

propyllithium; In diethyl ether; at 22 ℃; for 1h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.202008866

Reference yield:

2-fluorocinnamic acid (18944-77-9) → 1-fluoro-2-propylbenzene (912551-99-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 89 percent / HI-H₂O, red P

2: LiAlH₄ / diethyl ether

3: Et₃N / CH₂Cl₂

4: NaI / acetone

5: 1.) t-BuLi, 2.) MeOH / 1.) pentane, Et₂O, -78 deg C, 2.) -78 deg C

With methanol; phosphorus; lithium aluminium tetrahydride; hydrogen iodide; tert.-butyl lithium; triethylamine; sodium iodide; In diethyl ether; dichloromethane; acetone;

DOI:10.1021/jo972065z

upstream raw materials:

2-fluoro-1-(3-iodopropyl)benzene

3-(2-fluorophenyl)propionic acid

2-fluorocinnamic acid

3-(2-fluorophenyl)propan-1-ol

Downstream raw materials:

cis-(1S,2R)-1,2-dihydroxy-4-fluoro-3-propylcyclohexa-3,5-diene

Refernces

• 1、 Fukuyama, Takahide,Nishikawa, Tomohiro,Ryu, Ilhyong. "Site-Selective C(sp3)–H Functionalization of Fluorinated Alkanes Driven by Polar Effects Using a Tungstate Photocatalyst". supporting information. p. 1424 - 1428. Retrieved 2019/09/12.