(S)-methyl 3,3-dimethyl-2-methylene-1-(phenylcarbamoyl)cyclohexanecarboxylate

Base Information

Chemical Name:(S)-methyl 3,3-dimethyl-2-methylene-1-(phenylcarbamoyl)cyclohexanecarboxylate
CAS No.:1610839-60-5
Molecular Formula:C₁₈H₂₃NO₃
Molecular Weight:301.386
Hs Code.:

Synonyms:(S)-methyl 3,3-dimethyl-2-methylene-1-(phenylcarbamoyl)cyclohexanecarboxylate

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Chemical Property of (S)-methyl 3,3-dimethyl-2-methylene-1-(phenylcarbamoyl)cyclohexanecarboxylate

Chemical Property:

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Technology Process of (S)-methyl 3,3-dimethyl-2-methylene-1-(phenylcarbamoyl)cyclohexanecarboxylate

There total 10 articles about (S)-methyl 3,3-dimethyl-2-methylene-1-(phenylcarbamoyl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₇ClO₃

: 62-53-3
aniline

: 1610839-60-5
(S)-methyl 3,3-dimethyl-2-methylene-1-(phenylcarbamoyl)cyclohexanecarboxylate

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.1016/j.tetasy.2014.01.019

Reference yield:

: 147377-61-5
4-(1,3-dioxolan-2-yl)-1-iodo-4-methylpentane

: 1610839-60-5
(S)-methyl 3,3-dimethyl-2-methylene-1-(phenylcarbamoyl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid / water; acetone / 10 h / 50 °C

2.1: potassium carbonate / methanol / 12 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C

3.2: 4 h / 0 - 50 °C

4.1: triethylamine; tin(IV) chloride / dichloromethane / 14 h / 20 °C

5.1: pig liver esterase; water / aq. phosphate buffer / 6 h / 30 °C / pH 8 / Enzymatic reaction

6.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 9 h / -78 °C

7.1: dichloromethane / 20 °C

With pig liver esterase; oxalyl dichloride; water; tin(IV) chloride; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; aq. phosphate buffer; dichloromethane; water; acetone;
DOI:10.1016/j.tetasy.2014.01.019

Reference yield:

: 122471-54-9
3,3-Dimethyl-6-iodo-1-hexyne

: 1610839-60-5
(S)-methyl 3,3-dimethyl-2-methylene-1-(phenylcarbamoyl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C

1.2: 4 h / 0 - 50 °C

2.1: triethylamine; tin(IV) chloride / dichloromethane / 14 h / 20 °C

3.1: pig liver esterase; water / aq. phosphate buffer / 6 h / 30 °C / pH 8 / Enzymatic reaction

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 9 h / -78 °C

5.1: dichloromethane / 20 °C

With pig liver esterase; oxalyl dichloride; water; tin(IV) chloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; aq. phosphate buffer; dichloromethane;
DOI:10.1016/j.tetasy.2014.01.019