Technology Process of 2-Furanmethanol, 5-ethynyltetrahydro-, (2R,5R)- (9CI)
There total 12 articles about 2-Furanmethanol, 5-ethynyltetrahydro-, (2R,5R)- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 99 percent / H2 / PtO2 / ethyl acetate / 4 h / 20 °C / 2068.59 Torr
2: 92 percent / LiAlH4 / tetrahydrofuran / 3 h / 0 - 20 °C
3: 81 percent / IBX / dimethylsulfoxide / 4 h / 0 - 20 °C
4: 76 percent / benzene / 6 h / Heating
5: 88 percent / DIBAL-H / CH2Cl2; hexane / 2 h / -20 °C
6: 69 percent / (-)-DIPT; cumene hydroperoxide; molecular sieves 4 Angstroem / Ti(OiPr)4 / CH2Cl2 / 3 h / -20 °C
7: 88 percent / Ph3P; NaHCO3; CCl4 / 3 h / Heating
8: 80 percent / LDA / tetrahydrofuran; hexane / 3 h / -40 °C
9: 94 percent / Et3N / CH2Cl2 / 0.5 h / 0 - 20 °C
10: 90 percent / acetic acid / H2O / 12 h / 20 °C
11: 71 percent / Et3N / CH2Cl2 / 8 h / 20 °C
12: 75 percent / K2CO3 / methanol / 2 h / 20 °C
With
tetrachloromethane; lithium aluminium tetrahydride; Cumene hydroperoxide; 4 A molecular sieve; hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; D-(-)-diisopropyl tartrate; acetic acid; triethylamine; triphenylphosphine; lithium diisopropyl amide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
titanium(IV) isopropylate; platinum(IV) oxide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; benzene;
4: Wittig olefination;
DOI:10.1016/j.tetasy.2005.01.044
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 3 h / 0 - 20 °C
2: 81 percent / IBX / dimethylsulfoxide / 4 h / 0 - 20 °C
3: 76 percent / benzene / 6 h / Heating
4: 88 percent / DIBAL-H / CH2Cl2; hexane / 2 h / -20 °C
5: 69 percent / (-)-DIPT; cumene hydroperoxide; molecular sieves 4 Angstroem / Ti(OiPr)4 / CH2Cl2 / 3 h / -20 °C
6: 88 percent / Ph3P; NaHCO3; CCl4 / 3 h / Heating
7: 80 percent / LDA / tetrahydrofuran; hexane / 3 h / -40 °C
8: 94 percent / Et3N / CH2Cl2 / 0.5 h / 0 - 20 °C
9: 90 percent / acetic acid / H2O / 12 h / 20 °C
10: 71 percent / Et3N / CH2Cl2 / 8 h / 20 °C
11: 75 percent / K2CO3 / methanol / 2 h / 20 °C
With
tetrachloromethane; lithium aluminium tetrahydride; Cumene hydroperoxide; 4 A molecular sieve; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; D-(-)-diisopropyl tartrate; acetic acid; triethylamine; triphenylphosphine; lithium diisopropyl amide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
titanium(IV) isopropylate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; dimethyl sulfoxide; benzene;
3: Wittig olefination;
DOI:10.1016/j.tetasy.2005.01.044
