2-Methyl-2-[2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-cyclopentane-1,3-dione

Base Information

• Chemical Name: 2-Methyl-2-[2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-cyclopentane-1,3-dione
• CAS No.: 74766-16-8
• Molecular Formula: C₂₇H₂₅O₃P
• Molecular Weight: 428.467

Synonyms:2-Methyl-2-[2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-cyclopentane-1,3-dione

Chemical Property of 2-Methyl-2-[2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-cyclopentane-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2-Methyl-2-[2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-cyclopentane-1,3-dione

There total 4 articles about 2-Methyl-2-[2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-cyclopentane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Methylcyclopentane-1,3-dione (765-69-5) → 2-Methyl-2-[2-oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-cyclopentane-1,3-dione (74766-16-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 76 percent / DBU / Pd(Ph₃P)4 / toluene / 80 °C

2: NBS, H₂O / dimethylsulfoxide / 15 - 25 °C

3: benzene / 7 h / 80 °C

4: aq. K₂CO₃

With N-Bromosuccinimide; water; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dimethyl sulfoxide; toluene; benzene;

DOI:10.1021/ja00537a059

Reference yield:

2-(3-bromo-2-oxopropyl)-2-methylcyclopentane-1,3-dione (74766-13-5) → 2-Methyl-2-[2-oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-cyclopentane-1,3-dione (74766-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 7 h / 80 °C

2: aq. K₂CO₃

With potassium carbonate; In benzene;

DOI:10.1021/ja00537a059

Reference yield:

2-(2-Ethoxy-allyl)-2-methyl-cyclopentane-1,3-dione (74766-12-4) → 2-Methyl-2-[2-oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-cyclopentane-1,3-dione (74766-16-8)

Guidance literature:

Multi-step reaction with 3 steps

1: NBS, H₂O / dimethylsulfoxide / 15 - 25 °C

2: benzene / 7 h / 80 °C

3: aq. K₂CO₃

With N-Bromosuccinimide; water; potassium carbonate; In dimethyl sulfoxide; benzene;

DOI:10.1021/ja00537a059

upstream raw materials:

[3-(1-Methyl-2,5-dioxo-cyclopentyl)-2-oxo-propyl]-triphenyl-phosphonium; bromide

2-Methylcyclopentane-1,3-dione

2-(3-bromo-2-oxopropyl)-2-methylcyclopentane-1,3-dione

2-(2-Ethoxy-allyl)-2-methyl-cyclopentane-1,3-dione

Downstream raw materials:

(2R,6aS)-6a-Methyl-2-(2-methyl-allyl)-2-phenylsulfanyl-2,3,6,6a-tetrahydro-pentalene-1,5-dione

(2S,6aS)-6a-Methyl-2-phenylsulfanyl-2,3,6,6a-tetrahydro-pentalene-1,5-dione

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