Technology Process of {6-[2-(2-amino-3-hydroxypropyl)phenyl]hexyl}propanedioic acid 1-methyl ester
There total 9 articles about {6-[2-(2-amino-3-hydroxypropyl)phenyl]hexyl}propanedioic acid 1-methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 80 percent / t-BuOK / CH2Cl2 / 1 h / Ambient temperature
2: 6.9 g / LiAlH4 / 1 h
3: 6.3 g / pyridinium chlorochromate / CH2Cl2 / 0.5 h
4: 4.3 g / piperidine, benzoic acid / toluene / 6 h / Heating
5: 3.62 g / H2 / 10percent Pd/C / ethyl acetate / 17 h / 2585.7 Torr
6: 2.9 g / HCl (gas) / CH2Cl2 / Ambient temperature
With
piperidine; hydrogenchloride; lithium aluminium tetrahydride; potassium tert-butylate; hydrogen; benzoic acid; pyridinium chlorochromate;
palladium on activated charcoal;
In
dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jm960582o
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 98 percent / p-TsOH*H2O / CH2Cl2 / 48 h / Ambient temperature
2: 87 percent / n-BuLi / tetrahydrofuran / 1 h / -78 - 0 °C
3: 80 percent / t-BuOK / CH2Cl2 / 1 h / Ambient temperature
4: 6.9 g / LiAlH4 / 1 h
5: 6.3 g / pyridinium chlorochromate / CH2Cl2 / 0.5 h
6: 4.3 g / piperidine, benzoic acid / toluene / 6 h / Heating
7: 3.62 g / H2 / 10percent Pd/C / ethyl acetate / 17 h / 2585.7 Torr
8: 2.9 g / HCl (gas) / CH2Cl2 / Ambient temperature
With
piperidine; hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; potassium tert-butylate; hydrogen; toluene-4-sulfonic acid; benzoic acid; pyridinium chlorochromate;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jm960582o
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 87 percent / n-BuLi / tetrahydrofuran / 1 h / -78 - 0 °C
2: 80 percent / t-BuOK / CH2Cl2 / 1 h / Ambient temperature
3: 6.9 g / LiAlH4 / 1 h
4: 6.3 g / pyridinium chlorochromate / CH2Cl2 / 0.5 h
5: 4.3 g / piperidine, benzoic acid / toluene / 6 h / Heating
6: 3.62 g / H2 / 10percent Pd/C / ethyl acetate / 17 h / 2585.7 Torr
7: 2.9 g / HCl (gas) / CH2Cl2 / Ambient temperature
With
piperidine; hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; potassium tert-butylate; hydrogen; benzoic acid; pyridinium chlorochromate;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jm960582o
