3-[[[3-(1,1,2,2-Tetrafluoroethoxy)phenyl]methyl]amino]phenol

Base Information

Chemical Name:3-[[[3-(1,1,2,2-Tetrafluoroethoxy)phenyl]methyl]amino]phenol
CAS No.:263266-25-7
Molecular Formula:C₁₅H₁₃F₄NO₂
Molecular Weight:315.267
Hs Code.:
DSSTox Substance ID:DTXSID201185312

Synonyms:3-[[[3-(1,1,2,2-tetrafluoroethoxy)phenyl]methyl]amino]phenol;SCHEMBL3277887;DTXSID201185312;3-[[[3-(1,1,2,2-tetrafluoro-ethoxy)phenyl]methyl]amino]phenol;3-[[[3-(1,1,2,2-tetrafluoroethoxy)phenyl]methyl]amino] phenol;263266-25-7

Suppliers and Price of 3-[[[3-(1,1,2,2-Tetrafluoroethoxy)phenyl]methyl]amino]phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[[[3-(1,1,2,2-Tetrafluoroethoxy)phenyl]methyl]amino]phenol

Chemical Property:

XLogP3:4.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:315.08824131
Heavy Atom Count:22
Complexity:344

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC(=C1)OC(C(F)F)(F)F)CNC2=CC(=CC=C2)O

Technology Process of 3-[[[3-(1,1,2,2-Tetrafluoroethoxy)phenyl]methyl]amino]phenol

There total 1 articles about 3-[[[3-(1,1,2,2-Tetrafluoroethoxy)phenyl]methyl]amino]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 35295-35-3
3-(1,1,2,2-Tetrafluoroethoxy)-benzaldehyde

: 591-27-5
m-Hydroxyaniline

: 263266-25-7
3-{[3-(1,1,2,2-tetrafluoroethoxy)benzyl]amino}phenol

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 6h;
DOI:10.1021/jm020528+

Reference yield: 89.0%

: 359-41-1
1,1,1-trifluoro-2,3-epoxypropane

: 263266-25-7
3-{[3-(1,1,2,2-tetrafluoroethoxy)benzyl]amino}phenol

: 263344-11-2
(2R)-3-[[[3-(1,1,2,2-tetrafluoroethoxy]phenyl]methyl][3,3,3-trifluoro-2-hydroxy-propyl)amino]-phenol

Guidance literature:: With ytterbium(III) triflate; In acetonitrile; at 50 ℃; for 16h;
DOI:10.1021/jm020528+

Reference yield:

: 263266-25-7
3-{[3-(1,1,2,2-tetrafluoroethoxy)benzyl]amino}phenol

: 1,1,1-trifluoro-3-{(3-isopropoxy-phenyl)-[3-(1,1,2,2-tetrafluoro-ethoxy)-benzyl]-amino}-propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / Yb(OTf)3 / acetonitrile / 16 h / 50 °C

2: 59 percent / Cs₂CO₃ / acetonitrile / 48 h / 50 °C

With caesium carbonate; ytterbium(III) triflate; In acetonitrile;
DOI:10.1021/jm020528+