dimethyl [2-keto-(3R,4S,5R)-tri-O-benzyl-6(E),8-dienonon-1-yl]phosphonate

Base Information

• Chemical Name: dimethyl [2-keto-(3R,4S,5R)-tri-O-benzyl-6(E),8-dienonon-1-yl]phosphonate
• CAS No.: 1054614-20-8
• Molecular Formula: C₃₂H₃₇O₇P
• Molecular Weight: 564.615

Synonyms:dimethyl [2-keto-(3R,4S,5R)-tri-O-benzyl-6(E),8-dienonon-1-yl]phosphonate

Chemical Property of dimethyl [2-keto-(3R,4S,5R)-tri-O-benzyl-6(E),8-dienonon-1-yl]phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl [2-keto-(3R,4S,5R)-tri-O-benzyl-6(E),8-dienonon-1-yl]phosphonate

There total 2 articles about dimethyl [2-keto-(3R,4S,5R)-tri-O-benzyl-6(E),8-dienonon-1-yl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl 2,3,4-tri-O-benzyl-oct-5(E),7-dieno-D-xylonate + dimethyl methane phosphonate (756-79-6) → dimethyl [2-keto-(3R,4S,5R)-tri-O-benzyl-6(E),8-dienonon-1-yl]phosphonate (1054614-20-8)

Guidance literature:

dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

methyl 2,3,4-tri-O-benzyl-oct-5(E),7-dieno-D-xylonate; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

DOI:10.1016/S0957-4166(00)00084-7

Reference yield:

(2R,3S,4R,5E)-2,3,4-tribenzyloxyocta-5,7-diene-1-al (116384-34-0) → dimethyl [2-keto-(3R,4S,5R)-tri-O-benzyl-6(E),8-dienonon-1-yl]phosphonate (1054614-20-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Jones' reagent

2: 86 percent / BuLi / tetrahydrofuran / 0.25 h

With n-butyllithium; jones' reagent; In tetrahydrofuran;

DOI:10.1080/07328300600732782

Reference yield: 80.0%

methyl 6-aldehydo-2,3,4-tri-O-benzyl-α-D-glucopyranoside (83051-88-1) + dimethyl [2-keto-(3R,4S,5R)-tri-O-benzyl-6(E),8-dienonon-1-yl]phosphonate (1054614-20-8) → (2R,3S,4R)-2,3,4-Tris-benzyloxy-8-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-yl)-3,4,4a,7,8,8a-hexahydro-2H-naphthalen-1-one

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In toluene; at 20 ℃;

DOI:10.1016/S0957-4166(00)00084-7

upstream raw materials:

dimethyl methane phosphonate

(2R,3S,4R,5E)-2,3,4-tribenzyloxyocta-5,7-diene-1-al

Downstream raw materials:

(2S,2aS,5aS,6R,7S,8R,8aS,8bR)-6,7,8-Tris-benzyloxy-2-((4R,5R,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-2a,5a,6,7,8,8b-hexahydro-2H,3H-naphtho[1,8-bc]furan-8a-ol

(2R,3S,4R,5S,9S,10R)-{1-keto-2,3,4-tri-benzyloxy-6,7-ene-9-[(1'S)-5,5-dimethyl-2,4-dioxolane-1'-yl]}decalin

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1054614-20-8 dimethyl [2-keto-(3R,4S,5R)-tri-O-benzyl-6(E),8-dienonon-1-yl]phosphonate

Send

Send

Metric Ton KG G Pound L ML

Send

Send