N-(p-toluenesulfonyl)-4-chloro-6-methoxy-1,2-dihydroquinoline

Base Information

• Chemical Name: N-(p-toluenesulfonyl)-4-chloro-6-methoxy-1,2-dihydroquinoline
• CAS No.: 412337-45-2
• Molecular Formula: C₁₇H₁₆ClNO₃S
• Molecular Weight: 349.838
• Mol file: 412337-45-2.mol

Synonyms:N-(p-toluenesulfonyl)-4-chloro-6-methoxy-1,2-dihydroquinoline

Chemical Property of N-(p-toluenesulfonyl)-4-chloro-6-methoxy-1,2-dihydroquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-(p-toluenesulfonyl)-4-chloro-6-methoxy-1,2-dihydroquinoline

There total 3 articles about N-(p-toluenesulfonyl)-4-chloro-6-methoxy-1,2-dihydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-(3-chloro-2-propynyl)-N-(4-methoxyphenyl)-p-toluenesulfonamide → N-(p-toluenesulfonyl)-4-chloro-6-methoxy-1,2-dihydroquinoline (412337-45-2)

Guidance literature:

With tetrakis(trifluoroacetato)rhodium(II); In toluene; at 80 ℃; for 2h; regioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201303008

Reference yield:

3-[N-(4-methoxyphenyl)(p-toluene)sulfonamido]propanoic acid (6945-33-1) → N-(p-toluenesulfonyl)-4-chloro-6-methoxy-1,2-dihydroquinoline (412337-45-2)

Guidance literature:

With trichlorophosphate;

DOI:10.1021/ja01211a037

Reference yield:

→ N-(p-toluenesulfonyl)-4-chloro-6-methoxy-1,2-dihydroquinoline (412337-45-2)

Guidance literature:

With trichlorophosphate; at 100 ℃;

upstream raw materials:

3-[N-(4-methoxyphenyl)(p-toluene)sulfonamido]propanoic acid

Downstream raw materials:

6-methoxy-2,3-dihydroquinolin-4(1H)-one