N-(1-(8-bromoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butyl-3-fluorobenzenesulfonamide

Base Information

Chemical Name:N-(1-(8-bromoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butyl-3-fluorobenzenesulfonamide
CAS No.:1452183-67-3
Molecular Formula:C₂₃H₂₂BrFN₄O₂S
Molecular Weight:517.422
Hs Code.:

Synonyms:N-(1-(8-bromoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butyl-3-fluorobenzenesulfonamide

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Chemical Property of N-(1-(8-bromoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butyl-3-fluorobenzenesulfonamide

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Technology Process of N-(1-(8-bromoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butyl-3-fluorobenzenesulfonamide

There total 6 articles about N-(1-(8-bromoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butyl-3-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1452184-05-2
4-tert-butyl-3-fluorobenzene-1-sulfonyl chloride

: 1452184-12-1
1-(8-bromoquinolin-5-yl)-3-methyl-1H-pyrazol-5-amine

: 1452183-67-3
N-(1-(8-bromoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butyl-3-fluorobenzenesulfonamide

Guidance literature:: With pyridine; at 80 ℃; for 15h;

Reference yield:

: 1452184-11-0
8-bromo-5-hydrazinylquinoline

: 1452183-67-3
N-(1-(8-bromoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butyl-3-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 3 h / 80 °C

2: pyridine / 15 h / 80 °C

With pyridine; In ethanol;

Reference yield:

: 103392-84-3
2-tert-Butyl-5-nitro-phenylamine

: 1452183-67-3
N-(1-(8-bromoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butyl-3-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: nitrosonium tetrafluoroborate / dichloromethane / 2.08 h / 0 - 20 °C

1.2: 2 h / 75 °C / Dean-Stark

1.3: 0.17 h / 20 °C

2.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 3102.97 Torr

3.1: hydrogenchloride; sodium nitrite / water / 0.5 h / -15 °C

3.2: 2.08 h / -15 - 0 °C

4.1: pyridine / 15 h / 80 °C

With pyridine; hydrogenchloride; palladium 10% on activated carbon; nitrosonium tetrafluoroborate; hydrogen; sodium nitrite; In methanol; dichloromethane; water;