Technology Process of N-allyl-N-benzyloxycarbonyl-GABA
There total 2 articles about N-allyl-N-benzyloxycarbonyl-GABA which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(benzyloxycarbonylamino)butyric acid;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
Inert atmosphere;
allyl bromide;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 10h;
Inert atmosphere;
With
hydrogenchloride;
In
water; N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
pH=2;
Inert atmosphere;
DOI:10.1016/j.tet.2010.10.085
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydroxide / tetrahydrofuran; water / 3.5 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere
2.2: 1 h / 0 °C / Inert atmosphere
With
sodium hydride; sodium hydroxide;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acs.orglett.8b03777
- Guidance literature:
-
N-allyl-N-benzyloxycarbonyl-GABA;
With
ozone;
In
dichloromethane;
at -78 ℃;
for 1h;
With
dimethylsulfide;
In
dichloromethane;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1016/j.tet.2010.10.085
