(R)-7-(4-fluorophenyl)-7-(3-formyl-6-hydroxy-2,4,5-trimethylphenyl)heptanoic acid

Base Information

Chemical Name:(R)-7-(4-fluorophenyl)-7-(3-formyl-6-hydroxy-2,4,5-trimethylphenyl)heptanoic acid
CAS No.:156558-08-6
Molecular Formula:C₂₃H₂₇FO₄
Molecular Weight:386.463
Hs Code.:

Synonyms:(R)-7-(4-fluorophenyl)-7-(3-formyl-6-hydroxy-2,4,5-trimethylphenyl)heptanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-7-(4-fluorophenyl)-7-(3-formyl-6-hydroxy-2,4,5-trimethylphenyl)heptanoic acid

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Technology Process of (R)-7-(4-fluorophenyl)-7-(3-formyl-6-hydroxy-2,4,5-trimethylphenyl)heptanoic acid

There total 3 articles about (R)-7-(4-fluorophenyl)-7-(3-formyl-6-hydroxy-2,4,5-trimethylphenyl)heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 156483-02-2
methyl (R)-7-(4-fluorophenyl)-7-(3-formyl-6-hydroxy-2,4,5-trimethylphenyl)heptanoate

: 156558-08-6
(R)-7-(4-fluorophenyl)-7-(3-formyl-6-hydroxy-2,4,5-trimethylphenyl)heptanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; for 14h; Ambient temperature;
DOI:10.1248/cpb.44.749

Reference yield:

: 156558-16-6
methyl (S)-7-(4-fluorophenyl)-7-hydroxyheptanoate

: 156558-08-6
(R)-7-(4-fluorophenyl)-7-(3-formyl-6-hydroxy-2,4,5-trimethylphenyl)heptanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl azodicarboxylate, Ph₃P / 1,2-dichloro-ethane / 1 h / 10 °C

2: 75 percent / TiCl₄ / CH₂Cl₂ / 0.33 h / -12 - -10 °C

3: 93 percent / 1 N NaOH / tetrahydrofuran / 14 h / Ambient temperature

With sodium hydroxide; titanium tetrachloride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1248/cpb.44.749

Reference yield:

: 156482-91-6
methyl (R)-7-(4-fluorophenyl)-7-(2-hydroxy-3,4,6-trimethylphenyl)heptanoate

: 156558-08-6
(R)-7-(4-fluorophenyl)-7-(3-formyl-6-hydroxy-2,4,5-trimethylphenyl)heptanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / TiCl₄ / CH₂Cl₂ / 0.33 h / -12 - -10 °C

2: 93 percent / 1 N NaOH / tetrahydrofuran / 14 h / Ambient temperature

With sodium hydroxide; titanium tetrachloride; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.44.749