C₂₀H₁₅ClN₆O₂S₂

Base Information

• Chemical Name: C₂₀H₁₅ClN₆O₂S₂
• CAS No.: 1423161-72-1
• Molecular Formula: C₂₀H₁₅ClN₆O₂S₂
• Molecular Weight: 470.963
• Mol file: 1423161-72-1.mol

Synonyms:C₂₀H₁₅ClN₆O₂S₂

Chemical Property of C₂₀H₁₅ClN₆O₂S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₁₅ClN₆O₂S₂

There total 11 articles about C₂₀H₁₅ClN₆O₂S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-(4-chloro-2-(1-methyl-1H-pyrazol-5-yl)phenyl)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide (1423161-71-0) → C20H15ClN6O2S2 (1423161-72-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; for 0.5h;

Reference yield:

6-bromo-1H-indole (52415-29-9) → C20H15ClN6O2S2 (1423161-72-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 0.33 h / 10 °C / Inert atmosphere

1.2: 0.27 h / 10 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.25 h / Inert atmosphere; Cooling with acetone-dry ice

2.2: Inert atmosphere; Cooling with acetone-dry ice

2.3: 0.33 h / Cooling with ice

3.1: N-Bromosuccinimide / dichloromethane

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / Inert atmosphere; Cooling with acetone-dry ice

4.2: Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

6.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / 1,4-dioxane; water / 0.33 h / 90 °C / Inert atmosphere; Sealed tube

7.1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h

With hydrogenchloride; potassium phosphate; N-Bromosuccinimide; n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); tetrabutyl ammonium fluoride; sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

C28H37BrN4O4S2Si → C20H15ClN6O2S2 (1423161-72-1)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

2: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / 1,4-dioxane; water / 0.33 h / 90 °C / Inert atmosphere; Sealed tube

3: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h

With hydrogenchloride; potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; methanol; water;

upstream raw materials:

6-bromo-1H-indole

p-chloro-o-iodoaniline

4-chloro-2-(1-methyl-1H-pyrazol-5-yl)aniline

5-(2-bromo-5-chlorophenyl)-1-methyl-1H-pyrazole

Refernces