(R)-1-[4-(benzyloxy)-3-[(S)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy]benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(R)-1-[4-(benzyloxy)-3-[(S)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy]benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:1438250-74-8
Molecular Formula:C₄₅H₅₀N₂O₆
Molecular Weight:714.902
Hs Code.:

(R)-1-[4-(benzyloxy)-3-[(S)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy]benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Synonyms:(R)-1-[4-(benzyloxy)-3-[(S)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy]benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (R)-1-[4-(benzyloxy)-3-[(S)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy]benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (R)-1-[4-(benzyloxy)-3-[(S)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy]benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

There total 6 articles about (R)-1-[4-(benzyloxy)-3-[(S)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy]benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 13897-62-6
(S)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol

: 3755-58-6
(R)-1-(4-(benzyloxy)-3-bromobenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 1438250-74-8
(R)-1-[4-(benzyloxy)-3-[(S)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy]benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With pyridine; copper(I) bromide dimethylsulfide complex; caesium carbonate; for 20h; Reflux;
DOI:10.1248/cpb.c12-00820

Reference yield:

: 102922-34-9
2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 1438250-74-8
(R)-1-[4-(benzyloxy)-3-[(S)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy]benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -80 °C

1.2: 2 h / -98 - 0 °C

2.1: toluene-4-sulfonic acid; hydrazine hydrate / ethanol / 2 h / Reflux

3.1: sodium tetrahydroborate / methanol; water / 0 - 20 °C

4.1: pyridine; copper(I) bromide dimethylsulfide complex; caesium carbonate / 20 h / Reflux

With pyridine; sodium tetrahydroborate; n-butyllithium; copper(I) bromide dimethylsulfide complex; caesium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; In tetrahydrofuran; methanol; ethanol; hexane; water; 4.1: |Ullmann Condensation;
DOI:10.1248/cpb.c12-00820

Reference yield:

: C₂₅H₂₆BrNO₃

: 1438250-74-8
(R)-1-[4-(benzyloxy)-3-[(S)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy]benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol; water / 0 - 20 °C

2: pyridine; copper(I) bromide dimethylsulfide complex; caesium carbonate / 20 h / Reflux

With pyridine; sodium tetrahydroborate; copper(I) bromide dimethylsulfide complex; caesium carbonate; In methanol; water; 2: |Ullmann Condensation;
DOI:10.1248/cpb.c12-00820