Technology Process of (S)-N-Boc-3-hydroxyadamantylglycine-D-trans-4,5-methanoprolinamide
There total 1 articles about (S)-N-Boc-3-hydroxyadamantylglycine-D-trans-4,5-methanoprolinamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 8 steps
1.1: dmap
2.1: lithium triethylborohydride / toluene / -70 - -60 °C
3.1: dmap; trifluoroacetic anhydride; N-ethyl-N,N-diisopropylamine
4.1: diethylzinc / toluene; 1,2-dimethoxyethane; dichloromethane / -30 - 20 °C
5.1: lithium hydroxide monohydrate / ethanol; water / 2 h
6.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / tetrahydrofuran / 1 h
6.2: 1 h
7.1: isopropyl alcohol / 60 °C
8.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / ethyl acetate; acetonitrile / 3 h
With
dmap; lithium hydroxide monohydrate; diethylzinc; lithium triethylborohydride; benzotriazol-1-ol; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; ethyl acetate; isopropyl alcohol; toluene; acetonitrile;
DOI:10.1016/j.bmc.2013.12.061
