1,2-diphenylcyclopropanecarboxylic acid ethyl ester

Base Information

• Chemical Name: 1,2-diphenylcyclopropanecarboxylic acid ethyl ester
• CAS No.: 10224-12-1
• Molecular Formula: C₁₈H₁₈O₂
• Molecular Weight: 266.34
• Mol file: 10224-12-1.mol

Synonyms:1,2-diphenylcyclopropanecarboxylic acid ethyl ester

Chemical Property of 1,2-diphenylcyclopropanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1,2-diphenylcyclopropanecarboxylic acid ethyl ester

There total 5 articles about 1,2-diphenylcyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + ethyl 2-phenyl-2-(2-tosylhydrazono)acetate (849945-21-7) → 1,2-diphenylcyclopropanecarboxylic acid ethyl ester (10224-12-1)

Guidance literature:

With triethylamine; In water; at 20 ℃; for 24h; Irradiation;

DOI:10.1016/j.cclet.2021.05.031

Reference yield: 82.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + C44H8F20N4(2-)*C10H10O2*Fe(2+) → 1,2-diphenylcyclopropanecarboxylic acid ethyl ester (10224-12-1)

Guidance literature:

In benzene; at 60 ℃; for 15h;

DOI:10.1021/ja020391c

Reference yield:

1-bromovinylbenzene (98-81-7) → 1,2-diphenylcyclopropanecarboxylic acid ethyl ester (10224-12-1) + C18H18O2

Guidance literature:

Multi-step reaction with 3 steps

1.1: magnesium / tetrahydrofuran / 3 h / 60 °C

1.2: 3.5 h

2.1: N-phthaloyl-(s)-adamantylglycine / hexane / 0.5 h / 15 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 0 °C

With N-phthaloyl-(s)-adamantylglycine; tetrabutyl ammonium fluoride; magnesium; In tetrahydrofuran; hexane;

DOI:10.1021/acs.orglett.6b02117

upstream raw materials:

styrene

1-bromovinylbenzene

trimethyl(1-phenylvinyl)silane

ethyl 2-phenyl-2-(2-tosylhydrazono)acetate