(R)-1-(6-Amino-purin-9-yl)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propan-2-ol

Base Information

• Chemical Name: (R)-1-(6-Amino-purin-9-yl)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propan-2-ol
• CAS No.: 851050-22-1
• Molecular Formula: C₂₉H₂₉N₅O₄
• Molecular Weight: 511.58
• Mol file: 851050-22-1.mol

Synonyms:(R)-1-(6-Amino-purin-9-yl)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propan-2-ol

Chemical Property of (R)-1-(6-Amino-purin-9-yl)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-(6-Amino-purin-9-yl)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propan-2-ol

There total 1 articles about (R)-1-(6-Amino-purin-9-yl)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → (R)-1-(6-Amino-purin-9-yl)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propan-2-ol (851050-22-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 12 h

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 20 h / 110 °C

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1039/c8ra05568h

Reference yield:

(R)-1-(6-Amino-purin-9-yl)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propan-2-ol (851050-22-1) → Diisopropyl-phosphoramidous acid (R)-1-(6-benzoylamino-purin-9-ylmethyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl ester 2-cyano-ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1.1: Me₃SiCl; pyridine / 2 h / 20 °C

1.2: 53 percent / pyridine / 2 h / 20 °C

2.1: 66 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 2 h

With pyridine; chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/ja042564z

Reference yield:

(R)-1-(6-Amino-purin-9-yl)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propan-2-ol (851050-22-1) → C43H44N5O6PS2

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine; chloro-trimethyl-silane / 2 h / 20 °C

1.2: 2 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C

2.2: 24 h / 20 °C

With pyridine; chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1039/c8ra05568h

upstream raw materials:

4,4'-dimethoxytrityl chloride