(7R)-1-[(1'S,3a'S,6'S,7a'S)-1'-(1,1-dimethylethoxy)octahydro-7'a-methylspiro[1,3-dioxolane-2,5'-[5H]inden]-6'-yl]-7-(phenylmethoxy)-2-octanone

Base Information

Chemical Name:(7R)-1-[(1'S,3a'S,6'S,7a'S)-1'-(1,1-dimethylethoxy)octahydro-7'a-methylspiro[1,3-dioxolane-2,5'-[5H]inden]-6'-yl]-7-(phenylmethoxy)-2-octanone
CAS No.:944797-12-0
Molecular Formula:C₃₁H₄₈O₅
Molecular Weight:500.719
Hs Code.:

Synonyms:(7R)-1-[(1'S,3a'S,6'S,7a'S)-1'-(1,1-dimethylethoxy)octahydro-7'a-methylspiro[1,3-dioxolane-2,5'-[5H]inden]-6'-yl]-7-(phenylmethoxy)-2-octanone

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Chemical Property of (7R)-1-[(1'S,3a'S,6'S,7a'S)-1'-(1,1-dimethylethoxy)octahydro-7'a-methylspiro[1,3-dioxolane-2,5'-[5H]inden]-6'-yl]-7-(phenylmethoxy)-2-octanone

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Technology Process of (7R)-1-[(1'S,3a'S,6'S,7a'S)-1'-(1,1-dimethylethoxy)octahydro-7'a-methylspiro[1,3-dioxolane-2,5'-[5H]inden]-6'-yl]-7-(phenylmethoxy)-2-octanone

There total 5 articles about (7R)-1-[(1'S,3a'S,6'S,7a'S)-1'-(1,1-dimethylethoxy)octahydro-7'a-methylspiro[1,3-dioxolane-2,5'-[5H]inden]-6'-yl]-7-(phenylmethoxy)-2-octanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 944797-03-9
(1'S,3a'S,6'R,7a'S)-1'-(1,1-dimethylethoxy)octahydro-7'a-methyl-6'-[(7R)-7-(phenylmethoxy)-2-octenyl]-spiro[1,3-dioxolane-2,5'-[5H]indene]

: 944797-05-1
(7R)-1-[(1'S,3a'S,6'R,7a'S)-1'-(1,1-dimethylethoxy)octahydro-7'a-methylspiro[1,3-dioxolane-2,5'-[5H]inden]-6'-yl]-7-(phenylmethoxy)-3-octanone

: 944797-12-0
(7R)-1-[(1'S,3a'S,6'S,7a'S)-1'-(1,1-dimethylethoxy)octahydro-7'a-methylspiro[1,3-dioxolane-2,5'-[5H]inden]-6'-yl]-7-(phenylmethoxy)-2-octanone

Guidance literature:: (1'S,3a'S,6'R,7a'S)-1'-(1,1-dimethylethoxy)octahydro-7'a-methyl-6'-[(7R)-7-(phenylmethoxy)-2-octenyl]-spiro[1,3-dioxolane-2,5'-[5H]indene]; With borane-THF; In tetrahydrofuran; at 20 ℃; for 2h;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 0 - 20 ℃;

With sodium acetate; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 3h; Further stages.;
DOI:10.1021/jo070530e

Reference yield:

: 944797-01-7
(1S,3aS,6R,7aS)-1-(1,1-dimethylethoxy)octahydro-7a-methyl-6-(prop-2-enyl)-5H-inden-5-one

: 944797-12-0
(7R)-1-[(1'S,3a'S,6'S,7a'S)-1'-(1,1-dimethylethoxy)octahydro-7'a-methylspiro[1,3-dioxolane-2,5'-[5H]inden]-6'-yl]-7-(phenylmethoxy)-2-octanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 60 percent / second-generation Grubbs' catalyst / CH₂Cl₂ / Heating

2.1: 95 percent / PPTS / benzene / 14 h / Heating

3.1: borane-tetrahydrofuran complex / tetrahydrofuran / 2 h / 20 °C

3.2: NaOH; H₂O₂ / tetrahydrofuran; H₂O / 0 - 20 °C

3.3: 35 percent / PCC; NaOAc / CH₂Cl₂ / 3 h / 20 °C

With borane-THF; pyridinium p-toluenesulfonate; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/jo070530e

Reference yield:

: 944797-00-6
(R)-[[(1-methyl-5-hexenyl)oxy]methyl]-benzene

: 944797-12-0
(7R)-1-[(1'S,3a'S,6'S,7a'S)-1'-(1,1-dimethylethoxy)octahydro-7'a-methylspiro[1,3-dioxolane-2,5'-[5H]inden]-6'-yl]-7-(phenylmethoxy)-2-octanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 60 percent / second-generation Grubbs' catalyst / CH₂Cl₂ / Heating

2.1: 95 percent / PPTS / benzene / 14 h / Heating

3.1: borane-tetrahydrofuran complex / tetrahydrofuran / 2 h / 20 °C

3.2: NaOH; H₂O₂ / tetrahydrofuran; H₂O / 0 - 20 °C

3.3: 35 percent / PCC; NaOAc / CH₂Cl₂ / 3 h / 20 °C

With borane-THF; pyridinium p-toluenesulfonate; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/jo070530e