Benzoic acid (R)-1-((S)-1,2-dihydroxy-ethyl)-4-(tetrahydro-pyran-2-yloxy)-butyl ester

Base Information

Chemical Name:Benzoic acid (R)-1-((S)-1,2-dihydroxy-ethyl)-4-(tetrahydro-pyran-2-yloxy)-butyl ester
CAS No.:128694-41-7
Molecular Formula:C₁₈H₂₆O₆
Molecular Weight:338.401
Hs Code.:

Synonyms:Benzoic acid (R)-1-((S)-1,2-dihydroxy-ethyl)-4-(tetrahydro-pyran-2-yloxy)-butyl ester

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Chemical Property of Benzoic acid (R)-1-((S)-1,2-dihydroxy-ethyl)-4-(tetrahydro-pyran-2-yloxy)-butyl ester

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Technology Process of Benzoic acid (R)-1-((S)-1,2-dihydroxy-ethyl)-4-(tetrahydro-pyran-2-yloxy)-butyl ester

There total 6 articles about Benzoic acid (R)-1-((S)-1,2-dihydroxy-ethyl)-4-(tetrahydro-pyran-2-yloxy)-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 127280-22-2
{(2S,3S)-3-[3-(Tetrahydro-pyran-2-yloxy)-propyl]-oxiranyl}-methanol

: 65-85-0,8013-63-6
benzoic acid

: 128694-41-7
Benzoic acid (R)-1-((S)-1,2-dihydroxy-ethyl)-4-(tetrahydro-pyran-2-yloxy)-butyl ester

Guidance literature:: titanium(IV) isopropylate; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4039(00)94623-9

Reference yield:

: 51326-51-3
4-(tetrahydropyran-2-yloxy)butan-1-ol

: 128694-41-7
Benzoic acid (R)-1-((S)-1,2-dihydroxy-ethyl)-4-(tetrahydro-pyran-2-yloxy)-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: SO₃-Py, Et₃N / CH₂Cl₂; dimethylsulfoxide / 0.5 h / Ambient temperature

2: 83 percent / piperidine / pyridine / 2 h / 60 °C

3: 88 percent / DIBAL / diethyl ether; hexane / 0.5 h / 0 °C

4: 81 percent / Ti(OPr-i)4, (R,R)-(+)-diethyl tartrate, tert-butyl hydroperoxide / CH₂Cl₂; 2,2,4-trimethyl-pentane / 2 h / -20 °C

5: 80 percent / Ti(OPr-i)4 / CH₂Cl₂ / 4 h / Ambient temperature

With piperidine; titanium(IV) isopropylate; tert.-butylhydroperoxide; pyridine-SO₃ complex; diethyl (2R,3R)-tartrate; diisobutylaluminium hydride; triethylamine; In pyridine; 2,2,4-trimethylpentane; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo9619241

Reference yield:

: 66084-36-4
(E)-(R)-(tetrahydro-pyran-2-yloxy)-hex-2-en-1-ol

: 128694-41-7
Benzoic acid (R)-1-((S)-1,2-dihydroxy-ethyl)-4-(tetrahydro-pyran-2-yloxy)-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / Ti(OPr-i)4, (R,R)-(+)-diethyl tartrate, tert-butyl hydroperoxide / CH₂Cl₂; 2,2,4-trimethyl-pentane / 2 h / -20 °C

2: 80 percent / Ti(OPr-i)4 / CH₂Cl₂ / 4 h / Ambient temperature

With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; In 2,2,4-trimethylpentane; dichloromethane;
DOI:10.1021/jo9619241