(R)-2-[(6aS,11aR)-(7,8,9,10,11,11a-Hexahydro-5-oxa-11-aza-cyclohepta[a]naphthalen-6a-yl)amino]-2-phenyl-ethanol

Base Information

Chemical Name:(R)-2-[(6aS,11aR)-(7,8,9,10,11,11a-Hexahydro-5-oxa-11-aza-cyclohepta[a]naphthalen-6a-yl)amino]-2-phenyl-ethanol
CAS No.:592508-14-0
Molecular Formula:C₂₁H₂₆N₂O₂
Molecular Weight:338.45
Hs Code.:

Synonyms:(R)-2-[(6aS,11aR)-(7,8,9,10,11,11a-Hexahydro-5-oxa-11-aza-cyclohepta[a]naphthalen-6a-yl)amino]-2-phenyl-ethanol

Suppliers and Price of (R)-2-[(6aS,11aR)-(7,8,9,10,11,11a-Hexahydro-5-oxa-11-aza-cyclohepta[a]naphthalen-6a-yl)amino]-2-phenyl-ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (R)-2-[(6aS,11aR)-(7,8,9,10,11,11a-Hexahydro-5-oxa-11-aza-cyclohepta[a]naphthalen-6a-yl)amino]-2-phenyl-ethanol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-[(6aS,11aR)-(7,8,9,10,11,11a-Hexahydro-5-oxa-11-aza-cyclohepta[a]naphthalen-6a-yl)amino]-2-phenyl-ethanol

There total 6 articles about (R)-2-[(6aS,11aR)-(7,8,9,10,11,11a-Hexahydro-5-oxa-11-aza-cyclohepta[a]naphthalen-6a-yl)amino]-2-phenyl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 500131-67-9
(2R)-2-[(1S,12S)-10-oxa-2,16-diazatetracyclo[10.3.1.0^3,12.0^4,9]hexadeca-2,4⁽⁹⁾,5,7-tetraen-16-yl]-2-phenyl-1-ethanol

: 592508-14-0
(R)-2-[(6aS,11aR)-(7,8,9,10,11,11a-Hexahydro-5-oxa-11-aza-cyclohepta[a]naphthalen-6a-yl)amino]-2-phenyl-ethanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at -10 ℃; for 18h;
DOI:10.1016/S0040-4039(03)00890-6

Reference yield:

: 95-56-7
2-hydroxybromobenzene

: 592508-14-0
(R)-2-[(6aS,11aR)-(7,8,9,10,11,11a-Hexahydro-5-oxa-11-aza-cyclohepta[a]naphthalen-6a-yl)amino]-2-phenyl-ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / NaH; NaI / 1,2-dimethoxy-ethane / 5 h / 0 °C

2: 100 percent / sulfuryl chloride / CH₂Cl₂ / 1 h / 20 °C

3: 75 percent / LDA; HMPA / tetrahydrofuran / 0.5 h / -78 °C

4: 91 percent / n-BuLi / diethyl ether / -78 °C

5: 88 percent / lithium aluminium hydride / diethyl ether / 18 h / -10 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; n-butyllithium; sulfuryl dichloride; sodium hydride; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(03)00890-6

Reference yield:

: 54257-94-2
1-Bromo-2-chloro-methoxybenzene

: 592508-14-0
(R)-2-[(6aS,11aR)-(7,8,9,10,11,11a-Hexahydro-5-oxa-11-aza-cyclohepta[a]naphthalen-6a-yl)amino]-2-phenyl-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / LDA; HMPA / tetrahydrofuran / 0.5 h / -78 °C

2: 91 percent / n-BuLi / diethyl ether / -78 °C

3: 88 percent / lithium aluminium hydride / diethyl ether / 18 h / -10 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; n-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether;
DOI:10.1016/S0040-4039(03)00890-6