{6-[(6-methoxy-2',6'-dimethylbiphenyl-3-yl)methoxy]-2,3-dihydro-1-benzofuran-3-yl}acetic acid

Base Information

Chemical Name:{6-[(6-methoxy-2',6'-dimethylbiphenyl-3-yl)methoxy]-2,3-dihydro-1-benzofuran-3-yl}acetic acid
CAS No.:1347943-50-3
Molecular Formula:C₂₆H₂₆O₅
Molecular Weight:418.489
Hs Code.:

Synonyms:{6-[(6-methoxy-2',6'-dimethylbiphenyl-3-yl)methoxy]-2,3-dihydro-1-benzofuran-3-yl}acetic acid

Suppliers and Price of {6-[(6-methoxy-2',6'-dimethylbiphenyl-3-yl)methoxy]-2,3-dihydro-1-benzofuran-3-yl}acetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {6-[(6-methoxy-2',6'-dimethylbiphenyl-3-yl)methoxy]-2,3-dihydro-1-benzofuran-3-yl}acetic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of {6-[(6-methoxy-2',6'-dimethylbiphenyl-3-yl)methoxy]-2,3-dihydro-1-benzofuran-3-yl}acetic acid

There total 8 articles about {6-[(6-methoxy-2',6'-dimethylbiphenyl-3-yl)methoxy]-2,3-dihydro-1-benzofuran-3-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1350080-99-7
methyl {6-[(6-methoxy-2',6'-dimethylbiphenyl-3-yl)methoxy]-2,3-dihydro-1-benzofuran-3-yl}acetate

: 1347943-50-3
{6-[(6-methoxy-2',6'-dimethylbiphenyl-3-yl)methoxy]-2,3-dihydro-1-benzofuran-3-yl}acetic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃;
DOI:10.1021/jm2012968

Reference yield:

: 69716-04-7
2-(6-hydroxy-1-benzofuran-3-yl)acetic acid

: 1347943-50-3
{6-[(6-methoxy-2',6'-dimethylbiphenyl-3-yl)methoxy]-2,3-dihydro-1-benzofuran-3-yl}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / Reflux

2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

3: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 20 °C

4: sodium hydroxide / tetrahydrofuran; methanol; water / 20 °C

With tributylphosphine; sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; ethanol; water; toluene; 3: Mitsunobu reaction;
DOI:10.1021/jm2012968

Reference yield:

: 726174-52-3
(6-hydroxy-benzofuran-3-yl)-acetic acid methyl ester

: 1347943-50-3
{6-[(6-methoxy-2',6'-dimethylbiphenyl-3-yl)methoxy]-2,3-dihydro-1-benzofuran-3-yl}acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

2: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 20 °C

3: sodium hydroxide / tetrahydrofuran; methanol; water / 20 °C

With tributylphosphine; palladium 10% on activated carbon; hydrogen; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; ethanol; water; toluene; 2: Mitsunobu reaction;
DOI:10.1021/jm2012968