methyl 2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-carboxylate

Base Information

Chemical Name:methyl 2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-carboxylate
CAS No.:945531-15-7
Molecular Formula:C₂₁H₁₈FNO₈
Molecular Weight:431.374
Hs Code.:

Synonyms:methyl 2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-carboxylate

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Chemical Property of methyl 2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-carboxylate

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Technology Process of methyl 2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-carboxylate

There total 1 articles about methyl 2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 945531-13-5
methyl 4-hydroxy-3-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-carboxylate

: 945531-15-7
methyl 2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / diethyl ether; acetone / 1 h

2: 83 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In diethyl ether; acetone; acetonitrile;
DOI:10.1016/j.tet.2007.03.022

Reference yield: 90.0%

: 945531-15-7
methyl 2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-carboxylate

: 50602-41-0
3-hydroxy-4-methoxyphenethyl alcohol

Guidance literature:: With 1,3-dichlorotetrabutyldistannoxane; In toluene; for 20h; Heating;
DOI:10.1016/j.tet.2007.03.022

Reference yield:

: 945531-15-7
methyl 2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-carboxylate

: 4,4'-dihydroxy-3'-(4-hydroxyphenyl)spiro{2,10-dioxatricyclo[12.2.2.1^3,7]nonadeca-1⁽¹⁷⁾,3,5,7⁽¹⁹⁾,14⁽¹⁸⁾,15-hexaene-12,2'(5'H)-furan}-11,5'-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: 90 percent / 1,3-dichlorotetrabutyldistannoxane / toluene / 20 h / Heating

2.1: 61 percent / anhydrous K₂CO₃ / dimethylformamide / 3 h / 20 °C

3.1: 86 percent / H₂ / Pd/C / methanol; CHCl₃ / 16 h / 20 °C

4.1: 62 percent / tert-butyl nitrite / dimethylformamide / 0.33 h / Heating

5.1: BI₃ / CH₂Cl₂ / 0.5 h / 0 °C

5.2: 41 percent / H₂O / CH₂Cl₂

With tert.-butylnitrite; hydrogen; boron triiodide; 1,3-dichlorotetrabutyldistannoxane; potassium carbonate; palladium on activated charcoal; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2007.03.022