(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (5-oxotetrahydrofuran-3-yl)methyl carbonate

Base Information

Chemical Name:(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (5-oxotetrahydrofuran-3-yl)methyl carbonate
CAS No.:1620754-39-3
Molecular Formula:C₁₆H₂₆O₅
Molecular Weight:298.379
Hs Code.:

Synonyms:(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (5-oxotetrahydrofuran-3-yl)methyl carbonate

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Chemical Property of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (5-oxotetrahydrofuran-3-yl)methyl carbonate

Chemical Property:

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Technology Process of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (5-oxotetrahydrofuran-3-yl)methyl carbonate

There total 6 articles about (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (5-oxotetrahydrofuran-3-yl)methyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 36679-81-9
4-hydroxymethyl-1,2,3,4-tetrahydrofuran-2-one

: 14602-86-9,7635-53-2
(1R,2S,5R)-menthyl chloroformate

: 1620754-39-3
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (5-oxotetrahydrofuran-3-yl)methyl carbonate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/ejoc.201402218

Reference yield:

: 541-47-9
3-Methylbutenoic acid

: 1620754-39-3
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (5-oxotetrahydrofuran-3-yl)methyl carbonate

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / benzene / 2 h / 100 °C

2: sodium hydroxide / water / 20 °C

3: 15-crown-5 / acetonitrile / 20 °C

4: acetyl chloride / methanol / 20 °C

5: palladium on activated charcoal; hydrogen / methanol / 20 °C

6: pyridine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; 15-crown-5; palladium on activated charcoal; hydrogen; acetyl chloride; sodium hydroxide; dibenzoyl peroxide; In methanol; dichloromethane; water; acetonitrile; benzene;
DOI:10.1002/ejoc.201402218

Reference yield:

: 61934-55-2
3-bromomethyl-2-butenolide

: 1620754-39-3
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (5-oxotetrahydrofuran-3-yl)methyl carbonate

Guidance literature:: Multi-step reaction with 4 steps

1: 15-crown-5 / acetonitrile / 20 °C

2: acetyl chloride / methanol / 20 °C

3: palladium on activated charcoal; hydrogen / methanol / 20 °C

4: pyridine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With pyridine; 15-crown-5; palladium on activated charcoal; hydrogen; acetyl chloride; In methanol; dichloromethane; acetonitrile;
DOI:10.1002/ejoc.201402218