P-CHLOROCINNAMOYL CHLORIDE

Base Information

• Chemical Name: P-CHLOROCINNAMOYL CHLORIDE
• CAS No.: 35086-79-4
• Molecular Formula: C9H6 Cl2 O
• Molecular Weight: 201.052
• Hs Code.: 2916399090
• Mol file: 35086-79-4.mol

Synonyms:Cinnamoylchloride, p-chloro- (7CI); 3-[4-Chlorophenyl]propenoyl chloride;4-Chlorocinnamoyl chloride; p-Chlorocinnamic acid chloride; p-Chlorocinnamoylchloride

Chemical Property of P-CHLOROCINNAMOYL CHLORIDE

Chemical Property:

• PSA: 17.07000
• LogP: 3.11860

Purity/Quality:

99%, ^*data from raw suppliers

(2E)-3-(4-Chlorophenyl)acryloylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of P-CHLOROCINNAMOYL CHLORIDE

There total 9 articles about P-CHLOROCINNAMOYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

p-chlorocinnamic acid (1615-02-7,940-62-5) → p-chlorocinnamoyl chloride (35086-79-4)

Guidance literature:

With phosgene; In water; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2019.02.074

Reference yield: 100.0%

3-(4-chlorophenyl)prop-2-enoic acid (1615-02-7,940-62-5) → cinnamoyl chloride (35086-79-4,95602-71-4)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2009.08.047

Reference yield:

4-chlorobenzaldehyde (104-88-1) → p-chlorocinnamoyl chloride (35086-79-4)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / 3 h / Reflux

2: triethylamine; 1,3,5-trichloro-2,4,6-triazine / acetonitrile / 1 h / 20 °C

With piperidine; 1,3,5-trichloro-2,4,6-triazine; triethylamine; In acetonitrile; 1: |Knoevenagel Condensation;

DOI:10.1016/j.ejmech.2014.03.015

upstream raw materials:

p-chlorocinnamic acid

4-chlorobenzaldehyde

3-(4-chlorophenyl)prop-2-enoic acid

(E)-4-chlorocinnamic aldehyde

Downstream raw materials:

3-(4-chloro-phenyl)-N-(4-phenyl-thiazol-2-yl)-acrylamide

4-chlorocinnamaldehyde

3-(4-chlorophenyl)-N-(3,4,5-trimethoxyphenyl)acrylamide

4-chloro-trans-cinnamic acid-(4-amino-2-methyl-[6]quinolylamide)