(+/-)-2-((Z)-5-(4-((pyridin-2-ylcarbamoyl)methoxy)-3-methoxybenzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid

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Chemical Name:(+/-)-2-((Z)-5-(4-((pyridin-2-ylcarbamoyl)methoxy)-3-methoxybenzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid
CAS No.:1349200-09-4
Molecular Formula:C₂₇H₂₃N₃O₇S₂
Molecular Weight:565.628
Hs Code.:

Synonyms:(+/-)-2-((Z)-5-(4-((pyridin-2-ylcarbamoyl)methoxy)-3-methoxybenzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid

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Chemical Property of (+/-)-2-((Z)-5-(4-((pyridin-2-ylcarbamoyl)methoxy)-3-methoxybenzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid

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Technology Process of (+/-)-2-((Z)-5-(4-((pyridin-2-ylcarbamoyl)methoxy)-3-methoxybenzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid

There total 5 articles about (+/-)-2-((Z)-5-(4-((pyridin-2-ylcarbamoyl)methoxy)-3-methoxybenzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1224637-19-7
C₁₅H₁₄N₂O₄

: 305378-01-2
C₁₂H₁₁NO₄S₂

: 1349200-09-4
(+/-)-2-((Z)-5-(4-((pyridin-2-ylcarbamoyl)methoxy)-3-methoxybenzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid

Guidance literature:: With 1-methyl-piperazine; ammonium acetate; In toluene; at 110 ℃; for 15h; Molecular sieve;
DOI:10.1016/j.bioorg.2012.08.002

Reference yield:

: 5221-37-4
2-chloro-N-pyridin-2-ylacetamide

: 1349200-09-4
(+/-)-2-((Z)-5-(4-((pyridin-2-ylcarbamoyl)methoxy)-3-methoxybenzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 36 h / 35 - 40 °C

2: 1-methyl-piperazine; ammonium acetate / toluene / 15 h / 110 °C / Molecular sieve

With 1-methyl-piperazine; ammonium acetate; potassium carbonate; In acetone; toluene; 2: |Knoevenagel Condensation;
DOI:10.1016/j.bioorg.2012.08.002

Reference yield:

: 556-02-5,556-03-6,34537-57-0,55520-40-6,96946-98-4,60-18-4,18875-48-4,25619-78-7,30704-25-7
?Tyr

: 1349200-09-4
(+/-)-2-((Z)-5-(4-((pyridin-2-ylcarbamoyl)methoxy)-3-methoxybenzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; ammonia / 12.5 h / 0 - 5 °C

2.1: water / 0.5 h

2.2: 1 h / 5 - 10 °C

2.3: 3 h / 60 - 70 °C

3.1: 1-methyl-piperazine; ammonium acetate / toluene / 15 h / 110 °C / Molecular sieve

With 1-methyl-piperazine; ammonium acetate; ammonia; water; In water; toluene; 3.1: |Knoevenagel Condensation;
DOI:10.1016/j.bioorg.2012.08.002