(S)-4-benzenesulfonyl-1,1,1-trifluoro-2-<(methoxymethyl)oxy>-3-methyl-2-trifluoromethylbutane

Base Information

Chemical Name:(S)-4-benzenesulfonyl-1,1,1-trifluoro-2-<(methoxymethyl)oxy>-3-methyl-2-trifluoromethylbutane
CAS No.:156078-74-9
Molecular Formula:C₁₄H₁₆F₆O₄S
Molecular Weight:394.335
Hs Code.:

Synonyms:(S)-4-benzenesulfonyl-1,1,1-trifluoro-2-<(methoxymethyl)oxy>-3-methyl-2-trifluoromethylbutane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-benzenesulfonyl-1,1,1-trifluoro-2-<(methoxymethyl)oxy>-3-methyl-2-trifluoromethylbutane

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Technology Process of (S)-4-benzenesulfonyl-1,1,1-trifluoro-2-<(methoxymethyl)oxy>-3-methyl-2-trifluoromethylbutane

There total 6 articles about (S)-4-benzenesulfonyl-1,1,1-trifluoro-2-<(methoxymethyl)oxy>-3-methyl-2-trifluoromethylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 156078-73-8
(S)-1,1,1-trifluoro-2-<(methoxymethyl)oxy>-3-methyl-4-phenylthio-2-trifluoromethylbutane

: 156078-74-9
(S)-4-benzenesulfonyl-1,1,1-trifluoro-2-<(methoxymethyl)oxy>-3-methyl-2-trifluoromethylbutane

Guidance literature:: With disodium hydrogenphosphate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 6 ℃; for 0.666667h;
DOI:10.1248/cpb.43.1897

Reference yield:

: 156078-71-6
(R)-4,4,4-trifluoro-3-<(methoxymethyl)oxy>-2-methyl-3-trifluoromethylbutan-1-ol

: 156078-74-9
(S)-4-benzenesulfonyl-1,1,1-trifluoro-2-<(methoxymethyl)oxy>-3-methyl-2-trifluoromethylbutane

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / 4-(dimethylamino)pyridine, pyridine / 10 h / Ambient temperature

2: 1.) NaH / 1.) DMF, THF, RT, 10 min, 2.) DMF, THF, RT, 14 h

3: 98 percent / Na₂HPO₄, m-chloroperbenzoic acid / CH₂Cl₂ / 0.67 h / 6 °C

With pyridine; dmap; disodium hydrogenphosphate; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1248/cpb.43.1897

Reference yield:

: 156078-68-1
(R)-4,4,4-trifluoro-2-methyl-3-trifluoromethylbutane-1,3-diol

: 156078-74-9
(S)-4-benzenesulfonyl-1,1,1-trifluoro-2-<(methoxymethyl)oxy>-3-methyl-2-trifluoromethylbutane

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / imidazole / CH₂Cl₂ / 1 h / Ambient temperature

2: 81 percent / diisopropylethylamine / CH₂Cl₂ / 120 h / Ambient temperature

3: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / Ambient temperature

4: 97 percent / 4-(dimethylamino)pyridine, pyridine / 10 h / Ambient temperature

5: 1.) NaH / 1.) DMF, THF, RT, 10 min, 2.) DMF, THF, RT, 14 h

6: 98 percent / Na₂HPO₄, m-chloroperbenzoic acid / CH₂Cl₂ / 0.67 h / 6 °C

With pyridine; 1H-imidazole; dmap; disodium hydrogenphosphate; tetrabutyl ammonium fluoride; sodium hydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.43.1897