2-[N-(2-benzyloxycarbonylamino-propionyl)-N'-tert-butoxycarbonyl-hydrazino]-propionic acid methyl ester

Base Information

Chemical Name:2-[N-(2-benzyloxycarbonylamino-propionyl)-N'-tert-butoxycarbonyl-hydrazino]-propionic acid methyl ester
CAS No.:1026060-85-4
Molecular Formula:C₂₀H₂₉N₃O₇
Molecular Weight:423.466
Hs Code.:

2-[<i>N</i>-(2-benzyloxycarbonylamino-propionyl)-<i>N</i>'-<i>tert</i>-butoxycarbonyl-hydrazino]-propionic acid methyl ester

Synonyms:2-[N-(2-benzyloxycarbonylamino-propionyl)-N'-tert-butoxycarbonyl-hydrazino]-propionic acid methyl ester

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Chemical Property of 2-[N-(2-benzyloxycarbonylamino-propionyl)-N'-tert-butoxycarbonyl-hydrazino]-propionic acid methyl ester

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Technology Process of 2-[N-(2-benzyloxycarbonylamino-propionyl)-N'-tert-butoxycarbonyl-hydrazino]-propionic acid methyl ester

There total 5 articles about 2-[N-(2-benzyloxycarbonylamino-propionyl)-N'-tert-butoxycarbonyl-hydrazino]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 439916-87-7
(R)-2-[((S)-2-Benzyloxycarbonylamino-propionyl)-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-amino]-propionic acid methyl ester

: 1026060-85-4
2-[N-(2-benzyloxycarbonylamino-propionyl)-N'-tert-butoxycarbonyl-hydrazino]-propionic acid methyl ester

Guidance literature:: (R)-2-[((S)-2-Benzyloxycarbonylamino-propionyl)-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-amino]-propionic acid methyl ester; With pyrrolidine; In tetrahydrofuran; at 20 ℃;

di-tert-butyl dicarbonate; With dmap; In tetrahydrofuran; at 20 ℃;

With methylamine; In tetrahydrofuran; methanol; at 20 ℃; Further stages.;
DOI:10.1016/j.tet.2008.08.087

Reference yield:

: 439916-99-1
C₂₅H₃₇N₃O₉

: 1026060-85-4
2-[N-(2-benzyloxycarbonylamino-propionyl)-N'-tert-butoxycarbonyl-hydrazino]-propionic acid methyl ester

Guidance literature:: With magnesium chlorite; In acetonitrile;
DOI:10.1016/S0040-4039(02)00119-3

Reference yield:

: 17350-66-2
N-benzyloxycarbonylalaninehydrazid

: 1026060-85-4
2-[N-(2-benzyloxycarbonylamino-propionyl)-N'-tert-butoxycarbonyl-hydrazino]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 86 percent / DBAD; PPh₃ / tetrahydrofuran / 2 h / 0 - 20 °C

2.1: MeNH₂ / tetrahydrofuran / 3 h / 20 °C

2.2: 83 percent / DMAP / tetrahydrofuran / 20 °C

3.1: Mg(ClO₂)2 / acetonitrile

With magnesium chlorite; dibenzyl azodicarboxylate; triphenylphosphine; methylamine; In tetrahydrofuran; acetonitrile; 2.1: Mitsunobu reaction;
DOI:10.1016/S0040-4039(02)00119-3