8-bromo-N₂-(cyclohexylmethyl)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purine-2,6-diamine

Base Information

• Chemical Name: 8-bromo-N₂-(cyclohexylmethyl)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purine-2,6-diamine
• CAS No.: 1050495-22-1
• Molecular Formula: C₁₈H₂₇BrN₆O
• Molecular Weight: 423.356

Synonyms:8-bromo-N₂-(cyclohexylmethyl)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purine-2,6-diamine

Chemical Property of 8-bromo-N₂-(cyclohexylmethyl)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purine-2,6-diamine

Chemical Property:

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Technology Process of 8-bromo-N₂-(cyclohexylmethyl)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purine-2,6-diamine

There total 7 articles about 8-bromo-N₂-(cyclohexylmethyl)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purine-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N2-(cyclohexylmethyl)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purine-2,6-diamine (1050495-20-9) → 8-bromo-N2-(cyclohexylmethyl)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purine-2,6-diamine (1050495-22-1)

Guidance literature:

With N-Bromosuccinimide; In chloroform; at 20 ℃; for 1h;

Reference yield:

(tetrahydro-2H-pyran-4-yl)methanol (14774-37-9) → 8-bromo-N2-(cyclohexylmethyl)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purine-2,6-diamine (1050495-22-1)

Guidance literature:

Multi-step reaction with 4 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 - 43 °C

2: ammonia / isopropyl alcohol / 50 °C

3: 0.08 h / 170 °C / Microwave irradiation

4: N-Bromosuccinimide / chloroform / 1 h / 20 °C

With N-Bromosuccinimide; di-isopropyl azodicarboxylate; ammonia; triphenylphosphine; In tetrahydrofuran; chloroform; isopropyl alcohol;

Reference yield:

4-(bromomethyl)tetrahydro-2H-pyran (125552-89-8) → 8-bromo-N2-(cyclohexylmethyl)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purine-2,6-diamine (1050495-22-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 90 °C

2: 0.08 h / 170 °C / Microwave irradiation

3: N-Bromosuccinimide / chloroform / 1 h / 20 °C

With N-Bromosuccinimide; In chloroform; N,N-dimethyl-formamide;

upstream raw materials:

N₂-(cyclohexylmethyl)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purine-2,6-diamine

(tetrahydro-2H-pyran-4-yl)methanol

4-(bromomethyl)tetrahydro-2H-pyran

tetrahydropyran-4-carboxylic acid methyl ester

Downstream raw materials:

6-amino-2-[(cyclohexylmethyl)amino]-9-(tetrahydro-2H-pyran-4-ylmethyl)-7,9-dihydro-8H-purin-8-one

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