N-valeryl-N-[(2'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl)methyl]-L-phenylalanine methyl ester

Base Information

Chemical Name:N-valeryl-N-[(2'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl)methyl]-L-phenylalanine methyl ester
CAS No.:1374021-50-7
Molecular Formula:C₂₉H₃₃N₃O₄
Molecular Weight:487.599
Hs Code.:

Synonyms:N-valeryl-N-[(2'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl)methyl]-L-phenylalanine methyl ester

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Chemical Property of N-valeryl-N-[(2'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl)methyl]-L-phenylalanine methyl ester

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Technology Process of N-valeryl-N-[(2'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl)methyl]-L-phenylalanine methyl ester

There total 4 articles about N-valeryl-N-[(2'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl)methyl]-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.5%

: 1374021-45-0
N-valeryl-N-((2'-cyanobiphenyl-4-yl)methyl)-L-phenylalanine methyl ester

: 1374021-50-7
N-valeryl-N-[(2'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl)methyl]-L-phenylalanine methyl ester

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In dimethyl sulfoxide; at 90 ℃; for 16h;
DOI:10.1016/j.bmc.2012.02.003

Reference yield:

: 1374021-41-6
N-((2'-cyanobiphenyl-4-yl)methyl)-L-phenylalanine methyl ester

: 1374021-50-7
N-valeryl-N-[(2'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl)methyl]-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 20 - 45 °C / Inert atmosphere

2: hydroxylamine hydrochloride; triethylamine / dimethyl sulfoxide / 16 h / 90 °C

With dmap; hydroxylamine hydrochloride; triethylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2012.02.003

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 1374021-50-7
N-valeryl-N-[(2'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl)methyl]-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 0.5 h / 0 °C

1.2: 0 °C

2.1: triethylamine / N,N-dimethyl-formamide / 70 °C / Inert atmosphere; Cooling with ice

3.1: dmap; triethylamine / dichloromethane / 20 - 45 °C / Inert atmosphere

4.1: hydroxylamine hydrochloride; triethylamine / dimethyl sulfoxide / 16 h / 90 °C

With dmap; thionyl chloride; hydroxylamine hydrochloride; triethylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.02.003