tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-<1-<(4-methylphenyl)sulfonyl>-1H-pyrrol-2-yl>propanoate

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Chemical Name:tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-<1-<(4-methylphenyl)sulfonyl>-1H-pyrrol-2-yl>propanoate
CAS No.:161282-56-0
Molecular Formula:C₂₆H₃₀N₂O₆S
Molecular Weight:498.6
Hs Code.:

Synonyms:tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-<1-<(4-methylphenyl)sulfonyl>-1H-pyrrol-2-yl>propanoate

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Chemical Property of tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-<1-<(4-methylphenyl)sulfonyl>-1H-pyrrol-2-yl>propanoate

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Technology Process of tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-<1-<(4-methylphenyl)sulfonyl>-1H-pyrrol-2-yl>propanoate

There total 7 articles about tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-<1-<(4-methylphenyl)sulfonyl>-1H-pyrrol-2-yl>propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

: 161282-38-8
tert-butyl (Z)-2-<(benzyloxy)carbonylamino>-3-<1-<(4-methylphenyl)sulfonyl>-1H-pyrrol-2-yl>prop-2-enoate

: 161282-56-0
tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-<1-<(4-methylphenyl)sulfonyl>-1H-pyrrol-2-yl>propanoate

Guidance literature:: With hydrogen; BF4; In methanol; at 40 ℃; under 45003.6 Torr;
DOI:10.1002/hlca.19940770518

Reference yield:

: 1003-29-8,254729-95-8
2-pyrrole aldehyde

: 161282-56-0
tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-<1-<(4-methylphenyl)sulfonyl>-1H-pyrrol-2-yl>propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 96.5 percent / DMAP, (i-Pr)2EtN / CH₂Cl₂ / Ambient temperature

2: 64.9 percent / N,N,N',N'-tetramethylguanidine / 1,2-dimethoxy-ethane / 0.5 h / -30 °C

3: 95.2 percent / hydrogen / BF₄ / methanol / 40 °C / 45003.6 Torr

With dmap; hydrogen; N-ethyl-N,N-diisopropylamine; N,N,N',N'-tetramethylguanidine; BF4; In methanol; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1002/hlca.19940770518

Reference yield:

: 89525-07-5
(+/-)-2-<(benzyloxycarbonyl)amino>-2-(dimethoxyphosphinyl)acetic acid

: 161282-56-0
tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-<1-<(4-methylphenyl)sulfonyl>-1H-pyrrol-2-yl>propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 4-(dimethylamino)pyridine, dicyclohexylcarbodiimide / CH₂Cl₂ / 0 deg C -> room temperature

2: 64.9 percent / N,N,N',N'-tetramethylguanidine / 1,2-dimethoxy-ethane / 0.5 h / -30 °C

3: 95.2 percent / hydrogen / BF₄ / methanol / 40 °C / 45003.6 Torr

With dmap; hydrogen; dicyclohexyl-carbodiimide; N,N,N',N'-tetramethylguanidine; BF4; In methanol; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1002/hlca.19940770518