(S)-2-[2-(4-methylphenyl)acetamido]-3-phenylpropanoic acid methyl ester

Base Information

• Chemical Name: (S)-2-[2-(4-methylphenyl)acetamido]-3-phenylpropanoic acid methyl ester
• CAS No.: 1105566-58-2
• Molecular Formula: C₁₉H₂₁NO₃
• Molecular Weight: 311.381
• Mol file: 1105566-58-2.mol

Synonyms:(S)-2-[2-(4-methylphenyl)acetamido]-3-phenylpropanoic acid methyl ester

Chemical Property of (S)-2-[2-(4-methylphenyl)acetamido]-3-phenylpropanoic acid methyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[2-(4-methylphenyl)acetamido]-3-phenylpropanoic acid methyl ester

There total 1 articles about (S)-2-[2-(4-methylphenyl)acetamido]-3-phenylpropanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-tolylacetic acid (622-47-9) + methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → (S)-2-[2-(4-methylphenyl)acetamido]-3-phenylpropanoic acid methyl ester (1105566-58-2)

Guidance literature:

With dmap; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h;

Reference yield: 95.0%

(S)-2-[2-(4-methylphenyl)acetamido]-3-phenylpropanoic acid methyl ester (1105566-58-2) → (S)-2-[2-(4-methylphenyl)acetamido]-3-phenylpropanoic acid (1276020-62-2)

Guidance literature:

(S)-2-[2-(4-methylphenyl)acetamido]-3-phenylpropanoic acid methyl ester; With sodium hydroxide; In methanol; at 20 ℃; for 1h;

With hydrogenchloride; In water; pH=2;

DOI:10.1016/j.ejmech.2011.10.051

Reference yield:

(S)-2-[2-(4-methylphenyl)acetamido]-3-phenylpropanoic acid methyl ester (1105566-58-2) → CF201 (1276020-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol / 1 h / 20 °C

1.2: pH 2

2.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol;

DOI:10.1016/j.ejmech.2011.10.051

upstream raw materials:

4-tolylacetic acid

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

Downstream raw materials:

(S)-2-[2-(4-methylphenyl)acetamido]-3-phenylpropanoic acid

CF₂₀₁