(αR)-4-Fluoro-α-[(3S)-4-Methyl-3-[[(5-Methyl-3-isoxazolyl)carbonyl]aMino]-2-oxopentyl]-benzenepropanoic Acid

Base Information

Chemical Name:(αR)-4-Fluoro-α-[(3S)-4-Methyl-3-[[(5-Methyl-3-isoxazolyl)carbonyl]aMino]-2-oxopentyl]-benzenepropanoic Acid
CAS No.:328086-55-1
Molecular Formula:C₂₀H₂₃FN₂O₅
Molecular Weight:390.411
Hs Code.:
Mol file:328086-55-1.mol

Synonyms:(2R,5S)-2-(4-Fluoro-benzyl)-6-methyl-5-[(5-methyl-isoxazole-3-carbonyl)-amino]-4-oxo-heptanoic acid

Suppliers and Price of (αR)-4-Fluoro-α-[(3S)-4-Methyl-3-[[(5-Methyl-3-isoxazolyl)carbonyl]aMino]-2-oxopentyl]-benzenepropanoic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(αR)-4-Fluoro-α-[(3S)-4-methyl-3-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-2-oxopentyl]-benzenepropanoicAcid
5mg
$ 1320.00

Medical Isotopes, Inc.
(αR)-4-Fluoro-α-[(3S)-4-methyl-3-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-2-oxopentyl]-benzenepropanoicAcid
0.5 mg
$ 650.00

Total 1 raw suppliers

Chemical Property of (αR)-4-Fluoro-α-[(3S)-4-Methyl-3-[[(5-Methyl-3-isoxazolyl)carbonyl]aMino]-2-oxopentyl]-benzenepropanoic Acid

Chemical Property:

Boiling Point:605.4±55.0 °C(Predicted)
PKA:4.09±0.10(Predicted)
Density:1.251±0.06 g/cm3(Predicted)
Solubility.:Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:: (αR)-4-Fluoro-α-[(3S)-4-methyl-3-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-2-oxopentyl]-benzenepropanoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Intermediate in the preparation of rhinovirus protease inhibitors.

Technology Process of (αR)-4-Fluoro-α-[(3S)-4-Methyl-3-[[(5-Methyl-3-isoxazolyl)carbonyl]aMino]-2-oxopentyl]-benzenepropanoic Acid

There total 17 articles about (αR)-4-Fluoro-α-[(3S)-4-Methyl-3-[[(5-Methyl-3-isoxazolyl)carbonyl]aMino]-2-oxopentyl]-benzenepropanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 862414-84-4
allyl (2R,5S)-2-(4-fluorobenzyl)-6-methyl-5-{[(5-methyl-3-isoxazolyl)carbonyl]amino}-4-oxoheptanoate

: 328086-55-1
(2R,5S)-2-(4-Fluoro-benzyl)-6-methyl-5-[(5-methyl-isoxazole-3-carbonyl)-amino]-4-oxo-heptanoic acid

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 25 ℃; for 3h;
DOI:10.1016/j.bmc.2005.05.065

Reference yield: 72.0%

: 328273-13-8
(2R,5S)-5-Amino-2-(4-fluoro-benzyl)-6-methyl-4-oxo-heptanoic acid

: 39499-34-8
5-methyl-3-isoxazolyl chloride

: 328086-55-1
(2R,5S)-2-(4-Fluoro-benzyl)-6-methyl-5-[(5-methyl-isoxazole-3-carbonyl)-amino]-4-oxo-heptanoic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 10 ℃; for 2h;
DOI:10.1016/j.tetasy.2004.11.092

Reference yield:

: 124980-98-9
(R)-methyl 3-(4-fluorophenyl)-2-hydroxypropanoate

: 328086-55-1
(2R,5S)-2-(4-Fluoro-benzyl)-6-methyl-5-[(5-methyl-isoxazole-3-carbonyl)-amino]-4-oxo-heptanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 0.67 h / 0 °C

2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

2.2: tetrahydrofuran / 24 h / 0 - 20 °C

3.1: CF₃CO₂H / CH₂Cl₂ / 24 h / 20 °C

4.1: 83 percent / H₂ / Pd-C / methanol / 10 h / 20 °C

5.1: 90 percent / lithium hydroxide / H₂O; methanol / 1 h / 0 °C

6.1: 84 percent / Cs₂CO₃ / dimethylformamide / 5 h / 45 °C

7.1: HCl / dioxane / 2 h / 20 °C

8.1: 187 mg / 4-methylmorpholine / CH₂Cl₂ / 2 h / 25 °C

9.1: 85 percent / morpholine / Pd(PPh₃)4 / tetrahydrofuran / 3 h / 25 °C

With morpholine; 4-methyl-morpholine; 2,6-dimethylpyridine; hydrogenchloride; lithium hydroxide; hydrogen; sodium hydride; caesium carbonate; trifluoroacetic acid; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.05.065