N-<6-bromo-2-<<(4-bromo-2-fluorophenyl)methyl>amino>benzoyl>glycine methyl ester

Base Information

• Chemical Name: N-<6-bromo-2-<<(4-bromo-2-fluorophenyl)methyl>amino>benzoyl>glycine methyl ester
• CAS No.: 133166-94-6
• Molecular Formula: C₁₇H₁₅Br₂FN₂O₃
• Molecular Weight: 474.124

Synonyms:N-<6-bromo-2-<<(4-bromo-2-fluorophenyl)methyl>amino>benzoyl>glycine methyl ester

Chemical Property of N-<6-bromo-2-<<(4-bromo-2-fluorophenyl)methyl>amino>benzoyl>glycine methyl ester

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Technology Process of N-<6-bromo-2-<<(4-bromo-2-fluorophenyl)methyl>amino>benzoyl>glycine methyl ester

There total 3 articles about N-<6-bromo-2-<<(4-bromo-2-fluorophenyl)methyl>amino>benzoyl>glycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.6%

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + 6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-2H-3,1-benzoxazine-2,4(1H)-dione (133166-92-4) → N-<6-bromo-2-<<(4-bromo-2-fluorophenyl)methyl>amino>benzoyl>glycine methyl ester (133166-94-6)

Guidance literature:

With triethylamine; In toluene; at 100 ℃; for 4h;

DOI:10.1021/jm00108a038

Reference yield:

5-bromoisatoic anhydride (4692-98-2) → N-<6-bromo-2-<<(4-bromo-2-fluorophenyl)methyl>amino>benzoyl>glycine methyl ester (133166-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH (80percent dispersion in mineral oil) / 1.) DMF, 2 h, 2.) 8 h

2: 87.6 percent / Et₃N / toluene / 4 h / 100 °C

With sodium hydride; triethylamine; In toluene;

DOI:10.1021/jm00108a038

Reference yield:

4-bromo-2-fluorobenzyl bromide (76283-09-5) → N-<6-bromo-2-<<(4-bromo-2-fluorophenyl)methyl>amino>benzoyl>glycine methyl ester (133166-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH (80percent dispersion in mineral oil) / 1.) DMF, 2 h, 2.) 8 h

2: 87.6 percent / Et₃N / toluene / 4 h / 100 °C

With sodium hydride; triethylamine; In toluene;

DOI:10.1021/jm00108a038

upstream raw materials:

glycine ethyl ester hydrochloride

6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-2H-3,1-benzoxazine-2,4(1H)-dione

5-bromoisatoic anhydride

4-bromo-2-fluorobenzyl bromide

Downstream raw materials:

6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid methyl ester

6-bromo-1-<(4-bromo-2-fluorophenyl)methyl>-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid

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