(1S,2ξ,5S)-2-hydroxy-3-t-butyloxycarbonyl-7-benzyloxycarbonyl-3,7-diazabicyclo[3.3.1]nonane

Base Information

Chemical Name:(1S,2ξ,5S)-2-hydroxy-3-t-butyloxycarbonyl-7-benzyloxycarbonyl-3,7-diazabicyclo[3.3.1]nonane
CAS No.:251346-95-9
Molecular Formula:C₂₀H₂₈N₂O₅
Molecular Weight:376.453
Hs Code.:

Synonyms:(1S,2ξ,5S)-2-hydroxy-3-t-butyloxycarbonyl-7-benzyloxycarbonyl-3,7-diazabicyclo[3.3.1]nonane

Suppliers and Price of (1S,2ξ,5S)-2-hydroxy-3-t-butyloxycarbonyl-7-benzyloxycarbonyl-3,7-diazabicyclo[3.3.1]nonane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2ξ,5S)-2-hydroxy-3-t-butyloxycarbonyl-7-benzyloxycarbonyl-3,7-diazabicyclo[3.3.1]nonane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2ξ,5S)-2-hydroxy-3-t-butyloxycarbonyl-7-benzyloxycarbonyl-3,7-diazabicyclo[3.3.1]nonane

There total 6 articles about (1S,2ξ,5S)-2-hydroxy-3-t-butyloxycarbonyl-7-benzyloxycarbonyl-3,7-diazabicyclo[3.3.1]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 251346-94-8
(3S,5R)-3-hydroxymethyl-5-(t-butyloxycarbonyl)aminomethylpiperidine-1-carboxylic acid benzyl ester

: 251346-95-9
(1S,2ξ,5S)-2-hydroxy-3-t-butyloxycarbonyl-7-benzyloxycarbonyl-3,7-diazabicyclo[3.3.1]nonane

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -70 - 20 ℃;
DOI:10.1016/S0040-4020(99)00674-2

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 251346-95-9
(1S,2ξ,5S)-2-hydroxy-3-t-butyloxycarbonyl-7-benzyloxycarbonyl-3,7-diazabicyclo[3.3.1]nonane

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / 1N NaOH / tetrahydrofuran / 6 h / 20 °C

2: 90 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -70 - 20 °C

With sodium hydroxide; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 1: Acylation / 2: Oxidation;
DOI:10.1016/S0040-4020(99)00674-2

Reference yield:

: 206761-38-8
(3S,5R)-3-acetoxymethyl-5-hydroxymethylpiperidine-1-carboxylic acid benzyl ester

: 251346-95-9
(1S,2ξ,5S)-2-hydroxy-3-t-butyloxycarbonyl-7-benzyloxycarbonyl-3,7-diazabicyclo[3.3.1]nonane

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / pyridine / 4 h / 20 °C

2: 92 percent / NaN₃ / dimethylformamide / 8 h / 75 °C

3: 95 percent / SnCl₂ / methanol / 1 h / 20 °C

4: 94 percent / 1N NaOH / tetrahydrofuran / 6 h / 20 °C

5: 90 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -70 - 20 °C

With sodium hydroxide; sodium azide; oxalyl dichloride; dimethyl sulfoxide; triethylamine; tin(ll) chloride; In tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; 1: mesylation / 2: Substitution / 3: Reduction / 4: Acylation / 5: Oxidation;
DOI:10.1016/S0040-4020(99)00674-2