1-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-3-(pyridin-2-ylamino)-1H-pyrazole-4-carbonitrile

Base Information

Chemical Name:1-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-3-(pyridin-2-ylamino)-1H-pyrazole-4-carbonitrile
CAS No.:1413067-09-0
Molecular Formula:C₂₈H₂₅N₇O₂
Molecular Weight:491.552
Hs Code.:

Synonyms:1-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-3-(pyridin-2-ylamino)-1H-pyrazole-4-carbonitrile

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Chemical Property of 1-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-3-(pyridin-2-ylamino)-1H-pyrazole-4-carbonitrile

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Technology Process of 1-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-3-(pyridin-2-ylamino)-1H-pyrazole-4-carbonitrile

There total 3 articles about 1-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-3-(pyridin-2-ylamino)-1H-pyrazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 109-04-6
2-bromo-pyridine

: 1413067-01-2
3-amino-1-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrazole-4-carbonitrile

: 1413067-09-0
1-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-3-(pyridin-2-ylamino)-1H-pyrazole-4-carbonitrile

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; In tert-butyl alcohol; at 100 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1413066-93-9
1-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-formyl-phenyl]-3-(trityl-amino)-1H-pyrazole-4-carbonitrile

: 1413067-09-0
1-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-3-(pyridin-2-ylamino)-1H-pyrazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; methanol / dichloromethane / 0.25 h / 0 - 20 °C

2: hydrogenchloride / diethyl ether; methanol / 0.5 h / 0 °C

3: caesium carbonate / tris-(dibenzylideneacetone)dipalladium(0); dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine / tert-butyl alcohol / 2 h / 100 °C / Inert atmosphere

With hydrogenchloride; methanol; sodium tetrahydroborate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; In methanol; diethyl ether; dichloromethane; tert-butyl alcohol;

Reference yield:

: 1413066-97-3
1-[3-(6-tert-Butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-3-(trityl-amino)-1H-pyrazole-4-carbonitrile

: 1413067-09-0
1-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-3-(pyridin-2-ylamino)-1H-pyrazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / diethyl ether; methanol / 0.5 h / 0 °C

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium(0); dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine / tert-butyl alcohol / 2 h / 100 °C / Inert atmosphere

With hydrogenchloride; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; In methanol; diethyl ether; tert-butyl alcohol;