Technology Process of methyl 3-(6-chloro-1,2,3,4-tetrahydroquinolin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylate
There total 10 articles about methyl 3-(6-chloro-1,2,3,4-tetrahydroquinolin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 4 steps
1.1: hydrogenchloride; hydrogen / platinum(IV) oxide / ethanol; water / 20 °C
1.2: pH 8
2.1: 1-methyl-pyrrolidin-2-one / 1 h / 150 °C
3.1: pyridine / dichloromethane / 20 °C / Inert atmosphere
4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 1 h / 95 °C / Inert atmosphere
With
pyridine; hydrogenchloride; hydrogen; sodium carbonate;
platinum(IV) oxide; tetrakis(triphenylphosphine) palladium(0);
In
1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; ethanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C
2.1: hydrogen / palladium on activated charcoal / methanol / 0.5 h / 20 °C
3.1: 3 h / Reflux
4.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 110 °C
5.1: sulfuric acid / 20 °C
5.2: pH 7
6.1: 1-methyl-pyrrolidin-2-one / 1 h / 150 °C
7.1: pyridine / dichloromethane / 20 °C / Inert atmosphere
8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 1 h / 95 °C / Inert atmosphere
With
pyridine; sulfuric acid; hydrogen; sodium carbonate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0); palladium on activated charcoal;
In
1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: thionyl chloride / 0 °C / Reflux
2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C
3.1: hydrogen / palladium on activated charcoal / methanol / 0.5 h / 20 °C
4.1: 3 h / Reflux
5.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 110 °C
6.1: sulfuric acid / 20 °C
6.2: pH 7
7.1: 1-methyl-pyrrolidin-2-one / 1 h / 150 °C
8.1: pyridine / dichloromethane / 20 °C / Inert atmosphere
9.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 1 h / 95 °C / Inert atmosphere
With
pyridine; thionyl chloride; sulfuric acid; hydrogen; sodium carbonate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0); palladium on activated charcoal;
In
1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
