(±)-3-(4-cyclopropylphenoxy)-1-(4-hydroxy-3-methoxyphenyl)pyrrolidin-2-one

Base Information

Chemical Name:(±)-3-(4-cyclopropylphenoxy)-1-(4-hydroxy-3-methoxyphenyl)pyrrolidin-2-one
CAS No.:1574541-45-9
Molecular Formula:C₂₀H₂₁NO₄
Molecular Weight:339.391
Hs Code.:

Synonyms:(±)-3-(4-cyclopropylphenoxy)-1-(4-hydroxy-3-methoxyphenyl)pyrrolidin-2-one

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Chemical Property of (±)-3-(4-cyclopropylphenoxy)-1-(4-hydroxy-3-methoxyphenyl)pyrrolidin-2-one

Chemical Property:

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Technology Process of (±)-3-(4-cyclopropylphenoxy)-1-(4-hydroxy-3-methoxyphenyl)pyrrolidin-2-one

There total 4 articles about (±)-3-(4-cyclopropylphenoxy)-1-(4-hydroxy-3-methoxyphenyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1574541-44-8
(±)-3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-((2-(trimethylsilyl)ethoxy)methoxy)phenyl)pyrrolidin-2-one

: 1574541-45-9
(±)-3-(4-cyclopropylphenoxy)-1-(4-hydroxy-3-methoxyphenyl)pyrrolidin-2-one

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 755034-30-1
(2-((2-methoxy-4-nitrophenoxy)methoxy)ethyl)trimethylsilane

: 1574541-45-9
(±)-3-(4-cyclopropylphenoxy)-1-(4-hydroxy-3-methoxyphenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium on activated charcoal; hydrogen / ethyl acetate / 24 h / 20 °C

2.1: triethylamine / chloroform / 2 h / 20 °C / Inert atmosphere

2.2: AMBERLYST? IR-400 / 12 h / Inert atmosphere

2.3: 12 h / 55 °C / Inert atmosphere

3.1: hydrogenchloride / dichloromethane; diethyl ether / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; palladium on activated charcoal; hydrogen; triethylamine; In diethyl ether; dichloromethane; chloroform; ethyl acetate;

Reference yield:

: 3251-56-7
2-methoxy-4-nitrophenol

: 1574541-45-9
(±)-3-(4-cyclopropylphenoxy)-1-(4-hydroxy-3-methoxyphenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: palladium on activated charcoal; hydrogen / ethyl acetate / 24 h / 20 °C

3.1: triethylamine / chloroform / 2 h / 20 °C / Inert atmosphere

3.2: AMBERLYST? IR-400 / 12 h / Inert atmosphere

3.3: 12 h / 55 °C / Inert atmosphere

4.1: hydrogenchloride / dichloromethane; diethyl ether / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; palladium on activated charcoal; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; chloroform; ethyl acetate;